Section 13
Chapter 12,822

Standardization of an experimental murine model of invasive pulmonary aspergillosis

Sheppard, D.C.; Graybill, J.R.; Najvar, L.K.; Chiang, L.Y.; Doedt, T.; Kirkpatrick, W.R.; Bocanegra, R.; Vallor, A.C.; Patterson, T.F.; Filler, S.G.

Antimicrobial Agents and ChemoTherapy 50(10): 3501-3503


ISSN/ISBN: 0066-4804
PMID: 17005844
DOI: 10.1128/aac.00787-06
Accession: 012821445

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Evaluating new therapeutic agents for invasive aspergillosis requires animal models that are reproducible among different laboratories. We therefore evaluated a murine model of aerosol infection in two independent laboratories and found a high level of both intra- and interlaboratory reproducibility of survival, fungal burden over time, and the efficacy of liposomal amphotericin B.

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