+ Translate

Metabolic inflexibility in substrate use is present in African-American but not Caucasian healthy, premenopausal, nondiabetic women

, : Metabolic inflexibility in substrate use is present in African-American but not Caucasian healthy, premenopausal, nondiabetic women. Journal of Clinical Endocrinology and Metabolism 91(10): 4099-4106

Context: There is an increased prevalence of obesity and insulin resistance in African-American compared with Caucasian females. Metabolic inflexibility (MI) is the inability to switch the use of lipids and carbohydrates in the peripheral tissue (i.e. muscle) based upon substrate availability.Objective: We examined whether MI exists in African-American females.Main Outcome Measures and Design: We measured substrate use differences during eucaloric, macronutrient-manipulated diets [high fat (50% fat, 35% carbohydrate, 15% protein) vs. low fat (30% fat, 55% carbohydrate, 15% protein)] between Caucasian and African-American women. We also compared differences in substrate use in response to insulin infusion during two-step pancreatic-euglycemic clamps and epinephrine infusion during lipolysis studies. In each study, similar groups of Caucasian and African-American women were compared.Results: Caucasians had significantly higher fat oxidation (FO) (P = 0.01) and lower carbohydrate oxidation (P < 0.01) during the high-fat vs. low-fat diet, whereas no significant differences were observed in African-Americans. The African-American women also failed to significantly suppress FO during the second step of the pancreatic-euglycemic clamp despite a doubling of their fasting plasma insulin and failed to increase their FO or decrease their carbohydrate oxidation in response to epinephrine infusion as much as Caucasian women did. The response of free fatty acid turnover rates to insulin and epinephrine stimulation was similar between races.Conclusion: The impaired substrate use observed in African-American women during these three studies demonstrates the existence of MI and may contribute to their greater prevalence of obesity and insulin resistance.

(PDF 0-2 workdays service)

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 012872262

PMID: 16868062

DOI: 10.1210/jc.2005-2411

PDF Full Text: Submit

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Vysotskii, Ni, 1977: Influence of boar sperm quality on the reproductive capacity of sows and the quality of the progeny. Zhivotnovodstvo (12) 53-56

Samuels L.D.; Vig B.K., 1968: Specificity of daunomycin mutagen in causing chromosome aberrations in human leukocytes abstract. Genetics 60(1 PART 2): 220

Ogawa, Masahiko; Sakai, Tohru; Ohkuma, Kazuyuki; Matsumoto, Tadashi; Hisamatsu, Yoshiharu; Nakazawa, Hiroyuki, 1997: Rapid determination of multiple pesticide residues in agricultural products by GPC clean-up and GC/MS-SIM. A method for rapid determination of 95 kinds of pesticide residues in agricultural products by solvent extraction, GPC clean-up and GC/MS-SIM was developed. 1) A mixed solvent of acetone-ethyl acetate-n-hexane (2: 9: 9) was selected for extraction...

Koshcheenko, Ka; Baklashova, Tg; Kozlovskii, Ag, 1977: Hydroxylation of indole 3 acetic acid by the fungus Aspergillus niger IBPM F 12. Applied biochemistry and microbiology: (Transl 1977), 13 (2) 192-197

Godoi, Paulo-Hc; Galhardo, Rodrigo-S; Luche, Douglas-D; Van-Sluys, Marie-Anne; Menck, Carlos-Fm; Oliva, Glaucius, 2006: Structure of the Thiazole Biosynthetic Enzyme THI1 from Arabidopsis thaliana. Thiamin pyrophosphate is an essential coenzyme in all organisms that depend on fermentation, respiration or photosynthesis to produce ATP. It is synthesized through two independent biosynthetic routes: one for the synthesis of 2-methyl-4-amino-5-h...

Ostaficzuk S., 1975: The analysis of young tectonic movements by the concentrated contour technique. Pages 77-87:

Sauerbeck, D., 1958: The effect of a molybdenum application on the molybdenum content and the composition of several cultivated plants. Applications of sodium molybdate at the rate of 4 kg./ha. for the cure of whiptail generally exceed the requirements of cauliflower and are not fully absorbed by the crop. The largest part of the application remains in the soil and thus affects th...

Moraes Ruehsen, M. de; McNeill, R. E.; Frost, J. K.; Gupta, P. K.; Diamond, L. S.; Honigberg, B. M., 1980: Amebae resembling Entamoeba gingivalis in the genital tracts of IUD users. In Baltimore, USA, about 1% of 947 women wearing intra-uterine devices had amoebae in vaginopancervical smears, compared to none of 1164 women without such devices. In all cases there was concomitant Actinomyces infection. Both organisms disappear...

Deibert M. C., 1978: Environmental and regulatory aspects of project design and implementation. Pages 369 1978

Dixon, S. N.; Russell, K. L., 1986: Radioimmunoassay of the anabolic agent zeranol. IV. The determination of zeranol concentrations in the edible tissues of cattle implanted with zeranol (Ralgro). Rapid solvent extraction combined with a radioimmunoassay using a monoclonal antibody was used to measure residues in muscle, liver, kidney and fat of 4 cows slaughtered 70 days after implantation of 36 mg zeranol at the base of the ear. Highest z...