+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Relationship between coronary artery calcification detected by electron-beam computed tomography and abnormal stress echocardiography: association and prognostic implications



Relationship between coronary artery calcification detected by electron-beam computed tomography and abnormal stress echocardiography: association and prognostic implications



Journal of the American College of Cardiology 48(10): 2125-2131



The purpose of this study was to compare the results and prognostic value of electron-beam computed tomography (EBCT) and exercise echocardiography. Although patients with elevated coronary artery calcium scores (CACS) might be referred for exercise echocardiography, the association of EBCT CACS with wall motion score index (WMSI) is not known. Patients without known coronary artery disease who underwent both clinically indicated EBCT and exercise echocardiography within a 3-month period were identified. Exercise WMSI was based on a 16-segment model (normal = 1; abnormal >1). The EBCT CACS was derived with the Agatston scoring system. Follow-up was obtained for the combined end point of death and myocardial infarction. The study population included 556 patients (age 54 +/- 10 years; 65% male). Correlation between EBCT CACS and exercise WMSI was limited (r = 0.17, p < 0.0001) but statistically significant. The proportion of patients with abnormal exercise WMSI increased with increasing CACS severity (chi-square = 19.1, p < 0.001). However, even in those with CACS >400, 66% had normal exercise WMSI. Age, CACS, and chest pain were independently associated with abnormal exercise WMSI. Events occurred in 12 (2%) patients. Wall motion score index (risk ratio [RR] 3.7, p = 0.023) and age (RR 1.9, p = 0.019) were associated with events. Electron-beam computed tomography CACS was predictive of abnormal exercise WMSI, but the majority of patients with elevated CACS had normal WMSI. Wall motion score index and age were the best predictors of events. Prospective studies are indicated to establish the relative roles of these tests in risk stratification.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 012884057

Download citation: RISBibTeXText

PMID: 17113002

DOI: 10.1016/j.jacc.2006.04.105


Related references

Relationship and prognostic value of coronary artery calcification by electron beam computed tomography to stress-induced ischemia by single photon emission computed tomography. American Heart Journal 153(5): 807-814, 2007

Comparison of coronary artery calcification detected by electron beam computed tomography in coronary artery ectasia and in stenotic coronary artery disease. Zhonghua Xinxueguanbing Zazhi 32(1): 13-16, 2004

Detection of calcification by electron beam computed tomography in patients with coronary artery lesions due to Kawasaki disease Relationship between the acute coronary artery dilatation and the later appearance of calcification. Circulation 106(19 Suppl.): II-593-II-594, 2002

Coronary Artery Calcification Detected with Electron Beam Computed Tomography as a Marker for Coronary Artery Disease. Biomedical Engineering/ Biomedizinische Technik 39(S1): 207-208, 1994

Long-term prognostic value of coronary calcification detected by electron-beam computed tomography in patients undergoing coronary angiography. Circulation 104(4): 412-417, 2001

Long-term prognostic value of coronary calcification detected by electron beam computed tomography in patients undergoing coronary arteriography. Circulation 105(17): E127; Author Reply E127, 2002

Long-term prognostic value of coronary calcification detected by electron-beam computed tomography in patients undergoing coronary angiography. Acc Current Journal Review 11(1): 37-38, 2002

Long-term prognostic value of coronary calcification detected by electron beam computed tomography in patients with indications for coronary angiography. Circulation 102(18 Suppl.): II 397-II 398, 2000

Long-Term Prognostic Value of Coronary Calcification Detected by Electron Beam Computed Tomography in Patients Undergoing Coronary Arteriography * Response. Circulation 105(17): 127e-127, 2002

Impact of diabetes on coronary stenosis and coronary artery calcification detected by electron-beam computed tomography in symptomatic patients. Diabetes Care 25(4): 696-701, 2002

Relationships between coronary calcification detected at electron beam computed tomography and percutaneous transluminal coronary angioplasty results in coronary artery disease patients. European Radiology 13(1): 62-67, 2003

Stress echocardiography, stress sing le-photon-emission computed tomography and electron beam computed tomography for the assessment of coronary artery disease: A meta-analysis of diagnostic performance. American Heart Journal 154(3): 415-423, 2007

Severity of coronary artery calcification detected by electron beam computed tomography is related to the risk of restenosis after percutaneous transluminal coronary angioplasty. Internal Medicine 36(4): 255-262, 1997

Differential coronary artery calcification detected by electron beam computed tomography as an indicator of coronary stenosis among patients with stable angina pectoris. Canadian Journal of Cardiology 17(6): 667-676, 2001

Acute coronary artery dilation due to Kawasaki disease and subsequent late calcification as detected by electron beam computed tomography. Pediatric Cardiology 29(3): 568-573, 2008