+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Study on increase in toxicity of Schiff bases on microorganism on chelation with metal

Study on increase in toxicity of Schiff bases on microorganism on chelation with metal


New heterochelates of the type [M(L)(SB)(H2O)] (where M=Mn(II), Co(II), Ni(II), Cu(II), Zn(II), and Cd(II), KHL=potassium salt of salicylideneglycine and SB=thiophene-o-carboxaldeneaniline) have been synthesized. The heterochelates have been characterized on the basis of elemental analyses, electronic spectra, and magnetic measurement analyses. The structural and geometrical conformation has been discussed on the basis of IR spectral data. A thermal study of the complexes has been carried out to ascertain their thermal stability. Magnetic susceptibility measurements and electronic spectral data suggest a six-coordinated octahedral structure for these complexes. The increase in toxicity of the investigated heterochelate metal compounds was tested against three gram-negative bacteria, S. typhi, E. coli, and Serratia marcescens by the disc diffusion method. It is observed that the heterochelates show higher toxicity when compared to the Schiff bases, metal salts, and control (DMSO) due to chelation. The toxicity is also compared to the standard drug tetracycline.

(PDF emailed within 0-6 h: $19.90)

Accession: 012890032

Download citation: RISBibTeXText

DOI: 10.1080/02772240600556439

Related references

C-H activation in pyridoxal-5'-phosphate and pyridoxamine-5'-phosphate Schiff bases: effect of metal chelation. A computational study. Journal of Physical Chemistry. B 117(8): 2339-2347, 2013

The Effect Of Heavy Metal Halides On The Reaction Between Grignard Compounds And Schiff Bases. 11. On Reactions Of Schiff Bases. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 298: 26-33, 1965

Bactericidal activity of different oxovanadium(IV) complexes with Schiff bases and application of chelation theory. Journal of Enzyme Inhibition and Medicinal Chemistry 21(2): 203-209, 2006

Two photon carbon 13 and two dimensional proton nmr spectroscopic studies of retinyl schiff bases protonated schiff bases and schiff base salts evidence for a protonation induced pipi excited state level ordering reversal. Journal of the American Chemical Society 109(7): 2090-2101, 1987

Excited-state dynamics and two-photon absorption cross sections of fluorescent diphenyl-tin(IV) derivatives with schiff bases: a comparative study of the effect of chelation from the ultrafast to the steady-state time scale. Journal of Physical Chemistry. A 114(2): 704-714, 2009

Physico-chemical study of the reaction between transition metal ions and Schiff bases. Polarographic study of complexes of copper(II) with salicylidene-beta-alanine. Biofizika 25(2): 199-202, 1980

Phototriggered metal-ion release from phenolic Schiff bases: a system for metal-ion photodelivery. Chemphyschem 10(12): 1993-1995, 2009

Synthesis characterization and biological activity study of new schiff and mannich bases and some metal complexes derived from isatin and dithiooxamide. Bioinorganic Chemistry and Applications 2011: 706262-706262, 2011

Physicochemical studies on the interaction of transition metal ions with schiff bases a polarographic study of copper ii complexes of salicylidene alanine. Biofizika 25(2): 199-202, 1980

Spectroscopic study of the Schiff bases of dodecylamine with pyridoxal 5'-phosphate and 5'-deoxypyridoxal. A model for the Schiff bases of pyridoxal 5'-phosphate in biological systems. Biochemical Journal 279: 759-767, 1991

Visual pigments. 3. Determination and interpretation of the fluorescence quantum yields of retinals, Schiff bases, and protonated Schiff bases. Journal of the American Chemical Society 95(25): 8223-8227, 1973

Visual pigments part 3 determination and interpretation of the fluorescence quantum yields of retinals schiff bases and protonated schiff bases. Journal of the American Chemical Society 95(25): 8223-8227, 1973

Triferrocenes built on a C3-symmetric ligand platform: entry to redox-active pseudo-triphenylenes via chelation-driven stereoselection of triple Schiff bases. Inorganic Chemistry 46(5): 1694-1703, 2007

Spectroscopy of polyenes 3. absorption and emission spectral investigation of polyene schiff bases and protonated schiff bases related to visual pigments. Photochemistry and Photobiology 30(6): 689-696, 1979

Beta amino alcohols from amino acids chelation control via schiff bases. Tetrahedron Letters 31(35): 4985-4986, 1990