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Analysis of the transient response of a CSTR containing immobilized enzyme particles Part II. Minimum existence criterion and determination of substrate effective diffusivity and main reaction rate constant



Analysis of the transient response of a CSTR containing immobilized enzyme particles Part II. Minimum existence criterion and determination of substrate effective diffusivity and main reaction rate constant



Biochemical Engineering Journal 33(2): 116-125



A minimum existence criterion in the transient response of the bulk substrate concentration in a CSTR containing immobilized enzyme (IMEs) in porous solid supports has been obtained from simulation results using several kinetic expressions for the main reaction and the enzyme deactivation reaction. A simple method for the determination of the substrate effective diffusivity and the reaction rate constant is also presented, and applied to the decomposition of hydrogen peroxide, that reacts in a CSTR that contains silica-alumina porous catalyst particles, in which horseradish peroxidase enzyme had been previously immobilized.

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Accession: 012944326

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DOI: 10.1016/j.bej.2006.10.009


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