+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Dendritic cell immunoreceptors: C-type lectin receptors for pattern-recognition and signaling on antigen-presenting cells

Dendritic cell immunoreceptors: C-type lectin receptors for pattern-recognition and signaling on antigen-presenting cells

Journal of Dermatological Science 45(2): 77-86

C-type lectin receptors are equipped on phagocytes for antigen capturing. Some of them seem to have a major role in cellular activation, rather than antigen internalization. The dendritic cell (DC) immunoreceptor (DCIR) and DC-associated C-type lectin (dectin)-1 have been identified as prototypic DC-associated C-type lectin receptors, characterized by their signaling mechanisms through distinct intracellular motifs; the former contains the immunoreceptor tyrosine-based inhibitory motif (ITIM), to act as an inhibitory receptor, whereas the latter works as an activating receptor via its immunoreceptor tyrosine-based activation motif (ITAM). Genes of both receptors are localized very close to the natural killer (NK) gene complex (NKC), in which genes of lectin-type activating and inhibitory NK cell receptors are clustered. Recently, the gene of the DC immunoactivating receptor (DCAR) has been identified next to the DCIR gene, and this acts as a putative activating pair of DCIR through association with an ITAM-bearing Fc receptor (FcR) gamma chain. On the other hand, the gene of an ITIM-bearing myeloid inhibitory C-type lectin-like receptor (MICL) has been found close to the dectin-1 gene. The genes of other homologous DC-associated C-type lectin receptors, dectin-2 and blood DC antigen (BDCA)-2, form a cluster with those of DCIR and DCAR, while the dectin-1 gene cluster contains lectin-like oxidized low-density lipoprotein receptor (LOX)-1, C-type lectin-like receptor (CLEC)-1 and 2, as well as MICL. Although no ligand of DCIR has yet been identified, dectin-1 recognizes fungal beta-glucan and its critical role in the biological effects of beta-glucan has been vigorously investigated. In this review, the characteristic features of these DCIR and dectin-1 family lectins, including the signaling mechanisms, ligand recognition and regulation of cellular functions, are summarized and the term "DC immunoreceptors" is applied to a distinct set of signaling pattern-recognition receptors described here.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 012959498

Download citation: RISBibTeXText

PMID: 17046204

DOI: 10.1016/j.jdermsci.2006.09.001

Related references

DCIR DCAR Antigen presenting cells expressing lectin-type paired immunoreceptors. Journal of Investigative Dermatology 121(1): 0931, July, 2003

Ligand recognition by antigen-presenting cell C-type lectin receptors. Current Opinion in Immunology 17(1): 18-24, 2005

Fungal pattern-recognition receptors and tetraspanins: partners on antigen-presenting cells. Trends in Immunology 31(3): 91-96, 2011

Co-ordination of incoming and outgoing traffic in antigen-presenting cells by pattern recognition receptors and T cells. Traffic 12(12): 1669-1676, 2012

Coordination of incoming and outgoing traffic in antigen presenting cells by pattern recognition receptors and T cells. 2011

Influence of Core β-1,2-Xylosylation on Glycoprotein Recognition by Murine C-type Lectin Receptors and Its Impact on Dendritic Cell Targeting. Acs Chemical Biology 11(8): 2347-2356, 2016

A suppressor of cytokine signaling 1 antagonist enhances antigen-presenting capacity and tumor cell antigen-specific cytotoxic T lymphocyte responses by human monocyte-derived dendritic cells. Clinical and Vaccine Immunology 20(9): 1449-1456, 2014

De Novo Transcriptome Analysis Shows That SAV-3 Infection Upregulates Pattern Recognition Receptors of the Endosomal Toll-Like and RIG-I-Like Receptor Signaling Pathways in Macrophage/Dendritic Like TO-Cells. Viruses 8(4): 114-114, 2016

Fine discrimination in the recognition of individual species of phosphatidyl-myo-inositol mannosides from Mycobacterium tuberculosis by C-type lectin pattern recognition receptors. Journal of Immunology 177(3): 1805-1816, 2006

Myeloid dendritic cells display downregulation of C-type lectin receptors and aberrant lectin uptake in systemic lupus erythematosus. Arthritis Research & Therapy 10(5): R114-R114, 2008

Fusion of mature dendritic cells and human T-lymphotropic virus type I infected T cells: its efficiency as an antigen-presenting cell. Virology 301(1): 20, 2002

Ubiquitous versus restricted expression of the two mouse dendritic cell C-type lectin receptors, DCIR1 and DCAR2, among myeloid cells. Biochemical and Biophysical Research Communications 467(2): 383-388, 2016

CC chemokine receptors, CCR-1 and CCR-3, are potentially involved in antigen-presenting cell function of human peripheral blood monocyte-derived dendritic cells. Blood 93(1): 34-42, 1998

The fungal pattern recognition receptor, Dectin-1, and the associated cluster of C-type lectin-like receptors. Fems Microbiology Letters 290(2): 121-128, 2009