+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Differences in brain structure in deaf persons on MR imaging studied with voxel-based morphometry



Differences in brain structure in deaf persons on MR imaging studied with voxel-based morphometry



Ajnr. American Journal of Neuroradiology 28(2): 243-249



BACKGROUND AND PURPOSE: The loss of a major sensory input early in life is known to cause alterations in neuronal connectivity and physiology at the cellular level, but effects on gross anatomy are less well understood. The purpose of this study was to compare volumetric structural brain MR imaging scans of deaf versus hearing subjects by using voxel-based morphometry (VBM). The hypothesis was that the deaf would have relative hypoplasia in the temporal lobe centers involved in hearing and speech.METHODS: T1-weighted volumetric images from 53 prelingually deaf persons and 51 control subjects were analyzed with VBM. Initial segmentations were spatially normalized, and then these deformation parameters were applied to the original images, which were again segmented. Statistic parametric mapping was then applied on a voxel-by-voxel basis to determine group differences and asymmetries.RESULTS: The white matter analysis revealed a statistically significant focal deficit in the deaf persons in the left posterior superior temporal gyrus (STG), corresponding to white matter inferior to auditory cortex. Gray matter asymmetries in the deaf persons were overall similar to that in hearing persons but a focal loss of asymmetry was noted in the posterior STG white matter in the deaf persons.CONCLUSION: These results support the hypothesis that there are gross alterations in brain anatomy as a consequence of early deafness. The white matter deficit in the posterior left superior temporal gyrus may represent hypoplasia of the auditory/speech related tracts. Hemispheric asymmetries however remain largely intact.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 012961753

Download citation: RISBibTeXText

PMID: 17296987


Related references

Autism attenuates sex differences in brain structure: a combined voxel-based morphometry and diffusion tensor imaging study. Ajnr. American Journal of Neuroradiology 33(1): 83-89, 2012

The brain structure correlates of individual differences in trait mindfulness: a voxel-based morphometry study. Neuroscience 272: 21-28, 2014

Brain structure in autism: a voxel-based morphometry analysis of the Autism Brain Imaging Database Exchange (ABIDE). Brain Imaging and Behavior 11(2): 541-551, 2017

Association between the scores of the Japanese version of the Brief Assessment of Cognition in Schizophrenia and whole-brain structure in patients with chronic schizophrenia: A voxel-based morphometry and diffusion tensor imaging study. Psychiatry and Clinical Neurosciences 71(12): 826-835, 2017

Localizing Age-Related Changes in Brain Structure Using Voxel-Based Morphometry. Neural Plasticity 2017: 6303512, 2017

Schizotypy and brain structure: a voxel-based morphometry study. Psychological Medicine 40(9): 1423-1431, 2010

Structural brain differences in patients with schizophrenia and schizotypal disorder demonstrated by voxel-based morphometry. European Archives of Psychiatry and Clinical Neuroscience 254(6): 406-414, 2004

Combining voxel-based morphometry and diffusion tensor imaging to detect age-related brain changes. Neuroreport 17(5): 467-470, 2006

Age-related differences in regional brain volumes: a comparison of optimized voxel-based morphometry to manual volumetry. Neurobiology of Aging 30(10): 1657-1676, 2009

Differences in regional brain volume related to the extraversion-introversion dimension--a voxel based morphometry study. Neuroscience Research 72(1): 59-67, 2012

Voxel-based morphometry analysis reveals frontal brain differences in participants with ADHD and their unaffected siblings. Journal of Psychiatry and Neuroscience 41(4): 272-279, 2016

Voxel-based morphometry analysis reveals frontal brain differences in participants with Adhd and their unaffected siblings. Journal of Psychiatry & Neuroscience 41(4): 272-279, 2016

Voxel-based morphometry in the R6/2 transgenic mouse reveals differences between genotypes not seen with manual 2D morphometry. Neurobiology of Disease 33(1): 20-27, 2008

Progressive and widespread brain damage in ALS: MRI voxel-based morphometry and diffusion tensor imaging study. Amyotrophic Lateral Sclerosis 12(1): 59-69, 2011

Effects of tooth loss on brain structure: a voxel-based morphometry study. Journal of Prosthodontic Research 62(3): 337-341, 2018