+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Early resolution of herpes simplex virus type 2 infection of the murine genital tract involves stimulation of genital parenchymal cells by gamma interferon



Early resolution of herpes simplex virus type 2 infection of the murine genital tract involves stimulation of genital parenchymal cells by gamma interferon



Journal of Virology 81(1): 423-426



Early clearance of a thymidine kinase-deficient strain of herpes simplex virus type 2 from the female genital tract required T-cell-produced gamma interferon (IFN-gamma). Transfer of activated CD8+ T cells to irradiated C57BL/6 mice resulted in rapid virus clearance, but clearance was greatly delayed in recipients deficient in the IFN-gamma receptor (IFN-gammaR). Early virus clearance was demonstrated in radiation chimeras in which IFN-gammaR expression was limited to parenchymal cells, but resolution was significantly delayed in chimeras deficient in IFN-gammaR expression and chimeras expressing IFN-gammaR only on hematopoietic cells. Together, these results suggest that early IFN-gamma-mediated protection was manifested mainly by stimulation of genital parenchymal cells.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 012964558

Download citation: RISBibTeXText

PMID: 17065206

DOI: 10.1128/jvi.01455-06


Related references

Interferon-gamma enhances resolution of herpes simplex virus type 2 infection of the murine genital tract. Virology 229(1): 259-268, 1997

Interferon-c enhances resolution of herpes simplex virus type 2 infection of the murine genital tract. Virology 229: 9-68, 1997

Analysis of herpes simplex virus-specific T cells in the murine female genital tract following genital infection with herpes simplex virus type 2. Virology 212(2): 481-489, 1995

CD8+ T cells clear Herpes Simplex Virus type 2 from the female genital tract by an IFN- gamma dependent mechanism. FASEB Journal 18(4-5): Abst 554 20, 2004

Intravaginal infection with herpes simplex virus type-2 (HSV-2) generates a functional effector memory T cell population that persists in the murine genital tract. Journal of Reproductive Immunology 87(1-2): 39-44, 2011

Role for interleukin-18 and interferon-gamma in genital herpes simplex virus infection. Zhonghua Pifuke Zazhi 37(5): 270-272, May 15, 2004

Current Concepts for Genital Herpes Simplex Virus Infection: Diagnostics and Pathogenesis of Genital Tract Shedding. Clinical Microbiology Reviews 29(1): 149-161, 2016

Interleukin-12 (IL-12) and IL-18 are important in innate defense against genital herpes simplex virus type 2 infection in mice but are not required for the development of acquired gamma interferon-mediated protective immunity. Journal of Virology 75(14): 6705-6709, 2001

Differential roles of B cells and IFN-gamma-secreting CD4(+) T cells in innate and adaptive immune control of genital herpes simplex virus type 2 infection in mice. Journal of General Virology 82(Pt 4): 845-853, 2001

Genital reinfection after recovery from initial genital infection with herpes simplex virus type 2 in guinea pigs. Journal of Infectious Diseases 153(6): 1055-1061, 1986

Generation of humoral immune responses against herpes simplex virus type 2 in the murine female genital tract. Virology. 206(1): 234-241, 1995

Prepubertal vaccination of mice against experimental infection of the genital tract with type 2 herpes simplex virus. Archives of Virology 64(4): 329-338, 1980

Loss of the type I interferon pathway increases vulnerability of mice to genital herpes simplex virus 2 infection. Journal of Virology 85(4): 1625-1633, 2011

A prospective study of the relationship between genital herpes and carcinoma of the uterine cervix. I. Seroepidemiology of herpes simplex virus type 1 and type 2 in women with a previous history of clinically diagnosed genital herpes. Developments in Biological Standardization 52: 95-98, 1982

T-cell-mediated mechanisms involved in resolution of genital herpes simplex virus type 2 (HSV-2) infection of mice. Journal of Reproductive Immunology 61(2): 115-127, 2004