+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Frequency and significance of troponin T elevation in acute ischemic stroke

Frequency and significance of troponin T elevation in acute ischemic stroke

American Journal of Cardiology 99(1): 108-112

Elevated levels of troponin have been reported in patients with acute ischemic stroke. In this prospective study, the prevalence and characteristics of troponin elevation were examined in 244 patients with acute ischemic stroke but without overt ischemic heart disease. Troponin T (TnT) and creatine kinase-MB (CK-MB) concentrations were measured and 12-lead electrocardiograms obtained daily during the first 5 days of admission. Myocardial perfusion scintigraphy was performed in patients with TnT levels of 0.10 micro g/L and in comparable controls without elevation of TnT. Patients were followed for a mean of 19 +/- 7 months, with all-cause mortality as the clinical end point. Elevated levels of TnT (>0.03 micro g/L) and creatine kinase-MB (> or =10 micro g/L) were observed in 10% and 9% of patients, respectively. Patients with elevated TnT had higher frequencies of heart and/or renal failure. Perfusion abnormalities on myocardial perfusion scintigraphy at rest were not more frequent or pronounced in patients with TnT levels of > or =0.10 micro g/L than in the control group. Only 7 patients (3%) had elevations of TnT or creatine kinase-MB and electrocardiographic changes suggesting acute myocardial infarctions. According to univariate and multivariate analyses, elevation of TnT was significantly associated with mortality. In conclusion, elevated levels of TnT are rare in patients presenting with ischemic stroke but without overt ischemic heart disease. Heart and renal failure rather than myocardial infarction are the most likely causes. When present, elevation of TnT seems to be useful in identifying patients who are at increased risk of dying within the following 2 years.

(PDF emailed within 0-6 h: $19.90)

Accession: 012974786

Download citation: RISBibTeXText

PMID: 17196472

DOI: 10.1016/j.amjcard.2006.07.071

Related references

Insular cortex lesions, cardiac troponin, and detection of previously unknown atrial fibrillation in acute ischemic stroke: insights from the troponin elevation in acute ischemic stroke study. Stroke 46(5): 1196-1201, 2015

Coronary Angiographic Findings in Acute Ischemic Stroke Patients With Elevated Cardiac Troponin: The Troponin Elevation in Acute Ischemic Stroke (TRELAS) Study. Circulation 133(13): 1264-1271, 2016

The prognostic significance of troponin I elevation in acute ischemic stroke. Journal of Critical Care 31(1): 41-47, 2016

Elevation of troponin I in acute ischemic stroke. Peerj 4: E1866-E1866, 2016

Prognostic Significance of Troponin Elevation for Long-Term Mortality after Ischemic Stroke. Journal of Stroke 19(3): 312-322, 2017

Determinants of high sensitivity cardiac troponin T elevation in acute ischemic stroke. Bmc Neurology 14(): 96-96, 2015

Troponin elevation in acute ischemic stroke (TRELAS)--protocol of a prospective observational trial. Bmc Neurology 11(): 98-98, 2011

Frequency, determinants and outcome of elevated troponin in acute ischemic stroke patients. International Journal of Cardiology 157(2): 239-242, 2013

To study Troponin T levels and its significance in relation to mortality and morbidity in acute ischemic stroke. Indian Heart Journal 66: S120-S121, 2014

The clinical prognostic significance of hs-cTnT elevation in patients with acute ischemic stroke. Bmc Neurology 18(1): 118-118, 2018

Troponin elevation in ischemic stroke patients. Medizinische Klinik, Intensivmedizin und Notfallmedizin 112(3): 222-226, 2015

Takotsubo cardiomyopathy following ischemic stroke: a cause of troponin elevation. Journal of Neurology 259(1): 188-190, 2012

The significance of troponin elevation for the clinical course and outcome of first-ever ischaemic stroke. Cerebrovascular Diseases 38(3): 212-218, 2015

NETosis promotes cancer-associated arterial microthrombosis presenting as ischemic stroke with troponin elevation. Thrombosis Research 139(): 56-64, 2016

Ischemic Stroke with Troponin Elevation: Patient Characteristics, Resource Utilization, and In-Hospital Outcomes. Cerebrovascular Diseases 42(3-4): 213-223, 2016