+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Haemochromatosis gene (HFE) polymorphisms and migraine: an association study



Haemochromatosis gene (HFE) polymorphisms and migraine: an association study



Cephalalgia 27(1): 9-13



Several studies have suggested that iron metabolism may be involved in the pathogenesis of migraine. Using a case-control design, we performed an association study in a cohort of Italian migraine patients to evaluate whether a particular allele or genotype of the haemochromatosis gene (HFE) would modify the occurrence and clinical features of the disease. We genotyped 256 migraine patients and 237 healthy age-, sex- and ethnicity-matched controls for the C282Y and H63D polymorphisms of the HFE gene. Phenotype and allele frequencies of both polymorphisms were similarly distributed in migraine patients and controls. The patients carrying the DD genotype of the H63D polymorphism showed a later age at onset of the disease and an increased number of migraine attacks. Our data suggest that the HFE gene is not a major disease gene for migraine. However, the H63D polymorphism of the HFE gene may be considered a modifying genetic factor in migraine.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 012977998

Download citation: RISBibTeXText

PMID: 17212677

DOI: 10.1111/j.1468-2982.2006.01231.x


Related references

A candidate gene association study of 77 polymorphisms in migraine. Journal of Pain 10(7): 759-766, 2009

Single nucleotide polymorphisms of the serotonin transporter gene in migraine--an association study. Headache 50(2): 319-322, 2010

CACNA1A gene non-synonymous single nucleotide polymorphisms and common migraine in Italy: a case-control association study with a micro-array technology. Clinical Chemistry and Laboratory Medicine 47(6): 783-785, 2009

Association between migraine and HLA-DRB1 gene polymorphisms. Journal of Headache and Pain 6(4): 185-187, 2005

Association between polymorphisms in the beta2-adrenoceptor gene and migraine in women. Headache 49(2): 235-244, 2009

Association of single nucleotide polymorphisms of CACNA1A gene in migraine. Indian Journal of Human Genetics 20(1): 59-63, 2014

Association of 5-HTT gene polymorphisms with migraine: a systematic review and meta-analysis. Journal of the Neurological Sciences 305(1-2): 57-66, 2011

Genetic association of 5-HT1A and 5-HT1B gene polymorphisms with migraine in a Turkish population. Journal of the Neurological Sciences 326(1-2): 64-67, 2013

Association of the C677T and A1298C polymorphisms in the 5,10 methylenetetrahydrofolate reductase gene in patients with migraine risk. Molecular Brain Research 111(1-2): 84-90, 17 March, 2003

Association of MDR1, CYP2D6, and CYP2C19 gene polymorphisms with prophylactic migraine treatment response. Journal of the Neurological Sciences 366: 149-154, 2016

Association of oestrogen-receptor gene (ESR1) polymorphisms with migraine in the large Norfolk Island pedigree. Cephalalgia 33(14): 1139-1147, 2013

Lack of association between oxidative stress-related gene polymorphisms and chronic migraine in an Italian population. Expert Review of Neurotherapeutics 15(2): 215-225, 2015

Family-based association analysis of functional VNTR polymorphisms in the dopamine transporter gene in migraine with and without aura. Journal of Neural Transmission 115(1): 91-95, 2008

Idiopathic dilated cardiomyopathy: lack of association with haemochromatosis gene in the CARDIGENE study. Heart 86(6): 702-703, 2001