+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

In vitro activities of the novel oxazolidinones DA-7867 and DA-7157 against rapidly and slowly growing mycobacteria



In vitro activities of the novel oxazolidinones DA-7867 and DA-7157 against rapidly and slowly growing mycobacteria



Antimicrobial Agents and ChemoTherapy 50(12): 4027-4029



DA-7867 and DA-7157 are oxazolidinones active against pathogenic aerobic actinomycetes including Nocardia spp. and Mycobacterium tuberculosis. However, the activity of these drugs against nontuberculous mycobacterium (NTM) species is not known. In this work, we compared the susceptibilities of 122 clinical isolates and 29 reference species of both rapidly growing and slowly growing mycobacteria to linezolid, DA-7867, and DA-7157 by the broth microdilution method. The MICs for 50 and 90% of the strains tested (MIC50s and MIC90s, respectively) of DA-7867 and DA-7157 were lower than those of linezolid. In all of the cases, a MIC90 of <8 microg/ml was observed for all of the species tested in both groups of NTM. For M. kansasii and M. marinum isolates, the MIC90s of both DA-7867 and DA-7157 were less than 0.5 microg/ml. These results demonstrate the potential of these compounds to treat NTM infections.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 012982725

Download citation: RISBibTeXText

PMID: 17015632

DOI: 10.1128/AAC.00763-06


Related references

Usefulness of picric acid-sauton agar medium for differentiating slowly growing mycobacteria from rapidly growing mycobacteria. Tubercle 61(1): 33-35, 1980

In vitro activities of the ketolides telithromycin (HMR 3647) and HMR 3004 compared to those of clarithromycin against slowly growing mycobacteria at pHs 6.8 and 7.4. Antimicrobial Agents and ChemoTherapy 44(10): 2848-2852, 2000

In vitro activities of tigecycline and 10 other antimicrobials against nonpigmented rapidly growing mycobacteria. Antimicrobial Agents and ChemoTherapy 52(11): 4184-4186, 2008

Comparison of in vitro activities of gatifloxacin and ciprofloxacin against four taxa of rapidly growing mycobacteria. Antimicrobial Agents and ChemoTherapy 46(10): 3283-3285, 2002

Evaluation of methods for isolation of DNA from slowly and rapidly growing mycobacteria. International Journal of Leprosy and Other Mycobacterial Diseases 65(4): 469-476, 1998

In Vitro activities of isepamicin, other aminoglycosides, and capreomycin against clinical isolates of rapidly growing mycobacteria in Taiwan. Antimicrobial Agents and ChemoTherapy 51(5): 1849-1851, 2007

Structural analysis of biofilm formation by rapidly and slowly growing nontuberculous mycobacteria. Applied and Environmental Microbiology 75(7): 2091-2098, 2009

RETRACTED: Structural analysis of biofilm formation by rapidly and slowly growing nontuberculous mycobacteria. Applied and Environmental Microbiology: -, 2008

Classification and identification of slowly growing mycobacteria I Adansonian classification of slowly growing mycobacteria by forty-three characters. 1966

Activities of linezolid against rapidly growing mycobacteria. Antimicrobial Agents and ChemoTherapy 45(3): 764-767, 2001

In vitro activity of linezolid against slowly growing nontuberculous Mycobacteria. Antimicrobial Agents and ChemoTherapy 47(5): 1736-1738, 2003

Activities of clarithromycin against eight slowly growing species of nontuberculous mycobacteria, determined by using a broth microdilution MIC system. Antimicrobial Agents and ChemoTherapy 36(9): 1987-1990, 1992

Synergistic activities of tigecycline with clarithromycin or amikacin against rapidly growing mycobacteria in Taiwan. International Journal of Antimicrobial Agents 41(3): 218-223, 2013

In vitro activity of flomoxef against rapidly growing mycobacteria. Journal of ChemoTherapy 20(3): 303-306, 2008

In vitro activity of linezolid against isolates of rapidly growing mycobacteria. Abstracts of the General Meeting of the American Society for Microbiology 100: 654, 2000