EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Mice with experimental colitis show an altered metabolism with decreased metabolic rate



Mice with experimental colitis show an altered metabolism with decreased metabolic rate



American Journal of Physiology. Gastrointestinal and Liver Physiology 292(1): G165-G172



Patients with inflammatory bowel disease (IBD) suffer from body weight loss, malnutrition, and several other metabolic alterations affecting their quality of life. The aim of this study was to investigate the metabolic changes that may occur during acute and chronic colonic inflammation induced by dextran sulfate sodium (DSS) in mice. Clinical symptoms and inflammatory markers revealed the presence of an ongoing inflammatory response in the DSS-treated mice. Mice with acute inflammation had decreased body weight, respiratory exchange ratios (RER), food intake, and body fat content. Mice with chronic inflammation had decreased nutrient uptake, body fat content, locomotor activity, metabolic rates, and bone mineral density. Despite this, the body weight, food and water intake, lean mass, and RER of these mice returned to values similar to those in healthy controls. Thus, murine experimental colitis is associated with significant metabolic alterations similar to IBD patients. Our data show that the metabolic responses during acute and chronic inflammation are different, although the metabolic rate is reduced in both phases. These observations suggest compensatory metabolic alterations in chronic colitis resulting in a healthy appearance despite gross colon pathology.

(PDF emailed within 0-6 h: $19.90)

Accession: 012992461

Download citation: RISBibTeXText

PMID: 16844678

DOI: 10.1152/ajpgi.00152.2006



Related references

Adult BETA2/NeuroD1 null mice show decreased electroretinograms and altered morphology in the retina. IOVS 42(4): S181, March 15, 2001

Zonulin transgenic mice show altered gut permeability and increased morbidity/mortality in the DSS colitis model. Annals of the New York Academy of Sciences 1397(1): 130-142, 2017

Altered liver expression of genes involved in lipid and glucose metabolism in mice with partial IGF-1 deficiency: an experimental approach to metabolic syndrome. Journal of Translational Medicine 13(): 326-326, 2016

Mutant mice lacking the c isoform of protein kinase C show decreased behavioral actions of ethanol and altered function of c-aminobutyrate type A receptors. Proceedings of the National Academy of Sciences of the United States of America 92: 58-62, 1995

Decreased adipose tissue and altered metabolic function in Wnt-10b transgenic mice. Developmental Biology 247(2): 517, July 15, 2002

ENOS deficient mice show exaggerated disease activity in experimental colitis. Free Radical Biology & Medicine 33(Supplement 2): S345, 2002

Th17 cell accumulation is decreased during chronic experimental colitis by (n-3) PUFA in Fat-1 mice. Journal of Nutrition 142(1): 117-124, 2012

Mutant mice lacking the gamma isoform of protein kinase C show decreased behavioral actions of ethanol and altered function of gamma-aminobutyrate type A receptors. Proceedings of the National Academy of Sciences of the United States of America 92(9): 3658-3662, 1995

Decreased drug penetration in inflamed tissue related to changed mucosal metabolism in experimental colitis. Journal of Pharmaceutical Sciences 96(8): 2145-2153, 2007

The metabolic rate and thyroid size of chicks from dams with altered metabolism. Endocrinology 45(4): 396-402, 1949

Altered Brain Excitability and Increased Anxiety in Mice With Experimental Colitis: Consideration of Hyperalgesia and Sex Differences. Frontiers in Behavioral Neuroscience 12: 58-58, 2018

Decreased body weight and hepatic steatosis with altered fatty acid ethanolamide metabolism in aged L-Fabp -/- mice. Journal of Lipid Research 53(4): 744-754, 2012

Increased cerebral metabolic rate and decreased anoxic survival after aminophylline in young mice. Pediatric Research 12(4 PART 2): 536, 1978

Immunohistochemical analysis of altered serotonin signaling and transient receptor potential vanilloid 1 channels in experimental colitis mice. Yakugaku Zasshi 134(11): 1165-1170, 2015

Prion protein (PrP) knock-out mice show altered iron metabolism: a functional role for PrP in iron uptake and transport. Plos One 4(7): E6115-E6115, 2009