+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Positive troponin-T in noncompaction is associated with neuromuscular disorders and poor outcome

Positive troponin-T in noncompaction is associated with neuromuscular disorders and poor outcome

Clinical Research in Cardiology 96(2): 109-113

Though cardiac troponin-T may be positive in hypertrophic and dilated cardiomyopathy, it is not known how often troponin-T is positive in left ventricular hypertrabeculation/ noncompaction (LVHT), an unclassified cardiomyopathy. This retrospective study aimed to assess how often troponin-T is positive in LVHT, is associated with elevated CK, is attributable to cardiac or extra-cardiac causes, in particular neuromuscular disorders (NMDs), or if it is a predictor of poor survival. Among 100 patients, detected over a period of 11 years, troponin-T was determined at least once in 71 (71%) of them. Troponin-T was determined once in 36 patients, twice in 8 cases, three times in 11 patients, and more than three times in 16 cases. Troponin- T was positive at least once in 12 patients (17%). Forty-five of the 71 patients suffered from a NMD (63%). Troponin-T positivity was associated with elevated CK in 6 cases. Troponin-T-positivity was attributable to acute myocardial ischemia in a single case, to chronic renal failure in 5 cases, to dilated cardiomyopathy in 4 cases, to atrial fibrillation in 3 cases, to heart failure in 4 cases, and to NMD in 10 cases. Troponin-T positivity in LVHT patients with NMD was assumed to be due to cardiac involvement in the disease. Among the 22 patients who died during the observational period troponin was determined in 16 and was positive in 4 (25%). Troponin-T is positive in 17% of the patients with LVHT. Most of these patients suffer from a NMD. Troponin-T positivity in LVHT predicts the presence of NMD and poor survival.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 013004059

Download citation: RISBibTeXText

PMID: 17146603

DOI: 10.1007/s00392-006-0467-7

Related references

Noncompaction and neuromuscular disease with positive troponin-T in a nonagenerian. Clinical Cardiology 30(10): 527-528, 2007

Atrial fibrillation in left ventricular noncompaction with and without neuromuscular disorders is associated with a poor prognosis. International Journal of Cardiology 133(1): 41-45, 2009

Noncompaction in neuromuscular disorders is not at variance from noncompaction in chromosomal disorders, congenital, or non-hereditary disease. American Journal of Cardiology 109(7): 1083-4; Author Reply 1084-5, 2012

Chromosomal abnormalities and neuromuscular disorders predict severity and outcome of noncompaction in addition to cardiac comorbidities. Journal of the American Society of Echocardiography 23(3): 338; Author Reply 338-9, 2010

Consider neuromuscular disorders in association with noncompaction. Southern Medical Journal 100(7): 725-726, 2007

Coronary angiography in noncompaction with and without neuromuscular disorders. Irish Journal of Medical Science 180(3): 667-672, 2011

Ultrastructural findings in noncompaction prevail with neuromuscular disorders. Cardiology 126(4): 219-223, 2013

Hypertrabeculation is not distinct from noncompaction in neuromuscular and nonneuromuscular disorders. Journal of the American Society of Echocardiography 19(1): 109-110, 2006

Left ventricular hypertrabeculation/noncompaction with and without neuromuscular disorders. International Journal of Cardiology 97(1): 89-92, 2004

Neuromuscular disorders in left ventricular hypertrabeculation/noncompaction. Current Pharmaceutical Design 16(26): 2895-2904, 2010

Sex differences in left ventricular noncompaction in patients with and without neuromuscular disorders. Revista Espanola de Cardiologia 61(2): 130-136, 2008

Cardiac devices and neuromuscular disorders in left ventricular noncompaction. International Journal of Cardiology 148(1): 120-123, 2011

Acquired left ventricular noncompaction as a cardiac manifestation of neuromuscular disorders. Scandinavian Cardiovascular Journal 42(1): 25-30, 2008

Left ventricular noncompaction, cardiac magnetic resonance imaging, and neuromuscular disorders. Journal of the American College of Cardiology 47(6): 1233-4; Author Reply 1234-5, 2006

Noncompaction in Healthy Subjects, Dilated and Hypertrophic Cardiomyopathy, and Neuromuscular Disorders Is the Same Entity. Iranian Journal of Pediatrics 25(2): E511, 2015