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Regulation of expression and functional activity of G protein-coupled receptors. Alterations of these processes in diseases


, : Regulation of expression and functional activity of G protein-coupled receptors. Alterations of these processes in diseases. Biologicheskie Membrany (Moscow) 24(1): 4-31

Membrane receptors are the targets of most of the drugs used nowadays. However, the questions of how the receptor functions are altered in pathologies, what are the mechanisms of these alterations and how they are related to the development of the diseases, are studied only in a limited number of cases. G protein-coupled receptors (GPCR) comprise the biggest family of membrane receptors. Here the mechanisms of the regulation of the activity and expression of GPCRs are briefly reviewed. The data concerning the hereditary and oncological diseases caused by germinal and somatic mutations in the genes of the receptors and related proteins are presented. We discuss the relationship between the abnormalities in the receptor expression and functions occurring during ontogenesis and the development of diseases. In the final part of the review our data about the state of the receptors of vasoconstrictive hormones in blood vessels at traumatic shock are described.

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