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Synthesis and antibacterial activity of 3-(4-amino-5-methyl-s-triazol-3-sulfanyl)-1-phenyl-propan-1-one O-(5-substituted phenyl- oxadiazol-2-methyl)-oximes



Synthesis and antibacterial activity of 3-(4-amino-5-methyl-s-triazol-3-sulfanyl)-1-phenyl-propan-1-one O-(5-substituted phenyl- oxadiazol-2-methyl)-oximes



Yaoxue Xuebao 41(12): 1188-1192



Aim To study the synthetic method and antibacterial activity of amino-heterocyclic compounds coupled oxime-ether group. Methods The treatment of 4-amino-3-methyl-5-mercapto-s-triazole (3) with beta-chlorophenyl-propanone to form amino-s-triazole sulfanylphenyl-propanone (4) sequentially followed by oximation with hydroxyl-amine to produce the oximes (5) and etherification with various oxadiazole chloromethanes (6a - j) to yield the title compounds (1a - j). The in vitro antibacterial activities of all newly synthesized compounds were tested against Gram positive bacteria and Gram negative bacteria with the standard 2-fold agar dilution method. Results Twelve new compounds including two intermediates were synthesized and their structures were confirmed by IR, H-1 NMR, MS and elemental analyses. The ten title compounds exhibited the potential antibacterial activities in. vitro. Conclusion Theses compounds should be optimized.

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