+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Telomere length, risk of coronary heart disease, and statin treatment in the West of Scotland Primary Prevention Study: a nested case-control study



Telomere length, risk of coronary heart disease, and statin treatment in the West of Scotland Primary Prevention Study: a nested case-control study



Lancet 369(9556): 107-114



Inter-individual differences in biological ageing could affect susceptibility to coronary heart disease. Our aim was to determine whether mean leucocyte telomere length is a predictor of the development of coronary heart disease. We compared telomere lengths at recruitment in 484 individuals in the West of Scotland Primary Prevention Study (WOSCOPS) who went on to develop coronary heart disease events with those from 1058 matched controls who remained event free. We also investigated whether there was any association between telomere length and observed clinical benefit of statin treatment in WOSCOPS. Mean telomere length decreased with age by 9% per decade (95% CI 3.6-14.1; p=0.001) in controls; much the same trend was seen in cases (-5.9% per decade, -3.1 to 14.1; p=0.1902). Individuals in the middle and the lowest tertiles of telomere length were more at risk of developing a coronary heart disease event than were individuals in the highest tertile (odds ratio [OR] for coronary heart disease: 1.51, 95% CI 1.15-1.98; p=0.0029 in the middle tertile; 1.44, 1.10-1.90, p=0.0090 in the lowest). In placebo-treated patients, the risk of coronary heart disease was almost double in those in the lower two tertiles of telomere length compared with those in the highest tertile (1.93, 1.33-2.80, p=0.0005 in the middle tertile; 1.94, 1.33-2.84, p=0.0006 in the lowest). By contrast, in patients treated with pravastatin, the increased risk with shorter telomeres was substantially attenuated (1.12, 0.75-1.69, p=0.5755 in the middle tertile; 1.02, 0.68-1.52, p=0.9380 in the lowest). Mean leucocyte telomere length is a predictor of future coronary heart disease events in middle-aged, high-risk men and could identify individuals who would benefit most from statin treatment. Our findings lend support to the hypothesis that differences in biological ageing might contribute to the risk--and variability in age of onset--of coronary heart disease.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 013021117

Download citation: RISBibTeXText

PMID: 17223473

DOI: 10.1016/s0140-6736(07)60071-3


Related references

Telomere length, risk of coronary heart disease, and statin treatment in the West of Scotland Primary Prevention Study: a nested case-control study. Yearbook of Cardiology 2008: 296-298, 2008

Socioeconomic status and telomere length: the West of Scotland Coronary Prevention Study. Journal of Epidemiology and Community Health (1979-) 63(10): 839-841, 2009

Socioeconomic status and telomere length: the West of Scotland Coronary Prevention Study. Journal of Epidemiology and Community Health 63(10): 839-841, 2010

Primary prevention of coronary heart disease. What has WOSCOPS told us and what questions remain? West Of Scotland Coronary Prevention Study. Drugs 54(1): 1-8, 1997

Androgen deprivation therapy and the risk of coronary heart disease and heart failure in patients with prostate cancer: a nested case-control study in UK primary care. Drug Safety 34(11): 1061-1077, 2012

Is lipoprotein(a)-cholesterol a better predictor of vascular disease events than total lipoprotein(a) mass? A nested case control study from the West of Scotland Coronary Prevention Study. Atherosclerosis 148(1): 95-100, 1999

Interleukin-6 -174G>C polymorphism and risk of coronary heart disease in West of Scotland Coronary Prevention Study (WOSCOPS). Arteriosclerosis Thrombosis and Vascular Biology 22(4): 599-604, 2002

Interleukin-6-174G>C polymorphism and risk of coronary heart disease in west of Scotland coronary prevention study (WOSCOPS). Acc Current Journal Review 11(5): 28-0, 2002

Haemochromatosis gene mutations and risk of coronary heart disease: a west of Scotland coronary prevention study (WOSCOPS) substudy. Heart 90(3): 304-306, 2004

Telomere length and Parkinson's disease in men: a nested case-control study. European Journal of Neurology 21(1): 93-99, 2014

Mean telomere length and risk of incident venous thromboembolism: a prospective, nested case-control approach. Clinica Chimica Acta; International Journal of Clinical Chemistry 406(1-2): 148-150, 2009

Mean telomere length and risk of incident colorectal carcinoma: a prospective, nested case-control approach. Cancer Epidemiology, Biomarkers and Prevention 18(8): 2280-2282, 2009

Association of shorter mean telomere length with risk of incident myocardial infarction: a prospective, nested case-control approach. Clinica Chimica Acta; International Journal of Clinical Chemistry 403(1-2): 139-141, 2009

Mean leukocyte telomere length and risk of incident colorectal carcinoma in women: a prospective, nested case-control study. Clinical Chemistry and Laboratory Medicine 48(2): 259-262, 2010

Relative leukocyte telomere length and risk of incident ischemic stroke in men: a prospective, nested case-control approach. Rejuvenation Research 13(4): 411-414, 2010