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Effect of nitric oxide, vitamin E and selenium on streptozotocin induced diabetic rats

Nader, M.M.; Eissa, L.A.; Gamil, N.M.; Ammar, E.M.

Saudi Pharmaceutical Journal 15(1): 23-32

2007


ISSN/ISBN: 1319-0164
Accession: 013053753

Diabetes mellitus is characterized by a serious of complications that affect many organs. Aim: This study aimed to investigate the role of nitric oxide (NO) as a physiological mediator in the body via the use of L-arginine as NO precursor and NG-nitro-L-arginine methyl ester as nitric oxide synthase enzyme inhibitor in diabetic rats. The effect of vitamin E as antioxidant and selenium as a potent insulin-mimetic agent in diabetic rats were studied.

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