EurekaMag
+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Tabanidae
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

Effects of two different dosages of dobutamine on pulmonary artery wedge pressure, systemic arterial blood pressure and heart rate in anaesthetized horses


Effects of two different dosages of dobutamine on pulmonary artery wedge pressure, systemic arterial blood pressure and heart rate in anaesthetized horses



Journal of Veterinary Medicine. A Physiology Pathology Clinical Medicine 53(9): 476-480



ISSN/ISBN: 0931-184X

PMID: 17054485

DOI: 10.1111/j.1439-0442.2006.00860.x

The purpose of the present study was to investigate the effects of two different dobutamine concentrations on pulmonary artery wedge pressure (PAWP) and on mean systemic arterial blood pressure (MAP) in horses anaesthetized with isoflurane, after induction of general anaesthesia with xylazine, ketamine and diazepam. Eight healthy warm-blood horses were included in the study. Each horse was subjected to general anaesthesia twice with two different dosages of dobutamine, 3 and 5 microg/kg bw/min, being infused over 15 min, starting 50 min after induction of general anaesthesia (T(0)). The heart rate, the PAWP and the MAP were recorded after 10 min (T(1)) and then every 5 min until 15 min after cessation of intravenous dobutamine administration (T(3)-T(5)). The PAWP was measured by a right heart catheter, which was positioned in the pulmonary capillaries. Mean systemic arterial blood pressure was monitored at the facial artery for the duration of general anaesthesia. All parameters increased at both dosage rates of dobutamine and decreased significantly when dobutamine administration ceased. The increase in heart rate was significantly higher after administration of 3 microg/kg bw/min dobutamine compared with the dosage of 5 microg/kg bw/min dobutamine. The increase in MAP was also higher at this dosage, but not significantly different to the dosage of 5 microg/kg bw/min dobutamine. During both dosages the MAP was above a value considered to be compatible with good peripheral circulation. The greater increase in PAWP was observed during administration of 5 g/kg bw/min dobutamine, but PAWP was not significantly different with the dosage of 3 microg/kg bw/min dobutamine. In conclusion, the administration of dobutamine led to an increase in MAP and PAWP above a value considered to be compatible with a good peripheral circulation. The results of the present study indicate that dobutamine improves circulation, in addition to its well-known effect on the periphery.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 013115800

Download citation: RISBibTeXText

Related references

Pulmonary artery wedge pressure measurement during pharmacological stress induction with dobutamine and dobutamine/atropine in horses with and without heart disease. Deutsche Tieraerztliche Wochenschrift 113(7): 255-263, 2006

The effects of dobutamine and ephedrine on packed cell volume, total protein, heart rate, and blood pressure in anaesthetized horses. Journal of Veterinary Pharmacology and Therapeutics 21(6): 497-499, 1998

Effects of dobutamine on cardiac index and arterial blood pressure in isoflurane-anaesthetized horses under clinical conditions. Journal of Veterinary Pharmacology and Therapeutics 32(4): 353-358, 2009

Effect of detomidine on heart rate and pulmonary artery wedge pressure in horses. Pferdeheilkunde 22(3): 320-326, 2006

The effects of hemolyzed blood on pulmonary and systemic arterial pressure and heart rate of the dog. Canadian Journal of Comparative Medicine: Revue Canadienne de Medecine Comparee 42(1): 69-73, 1978

Pulmonary artery wedge pressure and heart rate measurement during pharmacological stress induction for left cardial function diagnosis in horses with and without heart disease. Dtw. Deutsche Tierarztliche Wochenschrift 113(7): 255-263, 2006

Experimental studies on lung capillary circulation after the ligation of a branch of pulmonary artery part 1 pulmonary venous wedge pressure vs systemic blood pressure. Polish Medical Journal (English Translation of Polskie Archiwum Medycyny Wewnetrznej) 9(3): 697-701, 1970

The effect of alkalosis on pulmonary artery pressure systemic artery pressure and arterial partial pressure of oxygen infants with persistent pulmonary hypertension. Pediatric Research 13(4 Part 2): 493, 1979

Effects of epidural opioid analgesics on heart rate, arterial blood pressure, respiratory rate, body temperature, and behavior in horses. Veterinary Therapeutics: Research in Applied Veterinary Medicine 4(4): 364-375, 2003

Effects of intravenous terbutaline on heart rate, arterial pressure and blood gases in anesthetized horses breathing air. Veterinary Anaesthesia and Analgesia 44(1): 70-76, 2017

Right atrial pressure/pulmonary artery wedge pressure ratio: A more specific predictor of survival in pulmonary arterial hypertension. Journal of Heart and Lung Transplantation: the Official Publication of the International Society for Heart Transplantation 35(6): 760-767, 2016

Systemic arterial blood pressure and heart rate responses to acute and chronic carotid or vertebral artery insulin infusion. FASEB Journal 8(4-5): A528, 1994

Pulmonary venous wedge pressure provides a safe and accurate estimate of pulmonary arterial pressure in children with shunt-dependent pulmonary blood flow. Catheterization and Cardiovascular Interventions: Official Journal of the Society for Cardiac Angiography and Interventions 74(5): 747-752, 2009

Influence of parietal pleura stimulation on systemic arterial blood pressure, pulmonary arterial blood pressure and on venous pressure. Fiziologicheskii Zhurnal SSSR Imeni I. M. Sechenova 52(9): 1073-1078, 1966

Pulmonary capillary wedge pressure and pulmonary arterial pressure in heart failure patients with sleep-disordered breathing. Sleep Medicine 10(7): 726-730, 2009