+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Fatal hemorrhagic diathesis associated with mild factor IX deficiency in pl



Fatal hemorrhagic diathesis associated with mild factor IX deficiency in pl



Comparative medicine 56(5): 426-434



Surgical implantation of devices into the abdomen of PL/J mice was associated with fatal hemorrhage at 9 to 11 d after surgery. Coagulation profiles were evaluated to determine the underlying cause of this effect. The mean activated partial thromboplastin time (aPTT) of untreated PL/J mice was significantly higher than that of BALB/cByJ and C57BL/6J strains. The addition of human plasmas deficient in factors VIII, XI, or XII, prekallikrein, or high molecular-weight kininogen corrected the elevated aPTT of PL/J mice, but correction did not occur when factor IX-deficient human plasma was added. When compared to an assigned factor IX activity of 100% for pooled plasma from BALB/cByJ mice, C57BL/6J and PL/J mice revealed percent activities of 67% and 16%, respectively. PL/J mice could represent a new model for the study of pathogenesis and therapy of mild factor IX deficiency that is expressed and becomes clinically apparent secondary to major surgery.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 013125224

Download citation: RISBibTeXText

PMID: 17069028


Related references

Factor 5 deficiency in hemorrhagic diathesis. Jour Amer Med Assoc 148(6): 462-463, 1952

Hemorrhagic diathesis due to factor VII deficiency. A.M.A. Archives of Internal Medicine 99(2): 280-284, 1957

Hemorrhagic diathesis associated with partial factor XII deficiency. Acta Haematologica Polonica 3(3): 257-263, 1972

Hemorrhagic diathesis caused by deficiency of factor VII. Probl Gematol I Perelivaniya Krovi : 163-172, 1962

Hemorrhagic diathesis due to factor VII deficiency (hypoproconvertinemia). Nederlands Tijdschrift Voor Geneeskunde 98(42): 2987-3001, 1954

Factor 13 deficiency with severe hemorrhagic diathesis. Blood 28(1): 34-39, 1966

Hemorrhagic diathesis due to a deficiency of Factor V (pro-accelerine). Nederlands Tijdschrift Voor Geneeskunde 112(16): 741-745, 1968

Hemorrhagic diathesis caused by a deficiency of the fibrin-stabilizing factor (factor 13). Verhandlungen der Deutschen Gesellschaft für Innere Medizin 74: 144-147, 1968

Hemorrhagic diathesis caused by a congenital deficiency of a new coagulation factor (Prower-Stuart factor). Helvetica Paediatrica Acta 12(3): 260-270, 1957

Hemorrhagic diathesis with prolonged bleeding time and deficiency of factor VIII and platelet factor 3. Harefuah 59: 337-338, 1960

Congenital factor VII -deficiency as a cause of a hemophilia-like hemorrhagic diathesis. Acta Haematol 16(3): 181-198, 1956

Hemorrhagic diathesis caused by factor VII (proconvertin) deficiency. Problems of Oncology. Voprosy Onkologii 6: 22-30, 1961

Hemorrhagic diathesis due to a familial, isolated Factor-XI(PTA)-deficiency. Die Medizinische Welt 24(17): 701-703, 1973

Familial hemorrhagic diathesis caused by factor X deficiency. Polski Tygodnik Lekarski 34(43): 1669-1670, 1979