EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Low plasma taurine concentration in Newfoundland dogs is associated with low plasma methionine and cyst(e)ine concentrations and low taurine synthesis



Low plasma taurine concentration in Newfoundland dogs is associated with low plasma methionine and cyst(e)ine concentrations and low taurine synthesis



Journal of Nutrition 136(10): 2525-2533



Although taurine is not dietarily essential for dogs, taurine deficiency and dilated cardiomyopathy (DCM) are sporadically reported in large-breed dogs. Taurine status and husbandry were examined in 216 privately owned Newfoundlands, a giant dog breed with high incidence of idiopathic DCM (1.3-2.5%). Plasma taurine concentration was positively correlated (P < 0.01) with plasma cyst(e)ine (r = 0.37) and methionine (r = 0.35) concentrations and was similar across age, sex, neutering status, body weight, and body-condition scores. Plasma taurine concentration was low (< or =40 micromol/L) in 8% of dogs. Dogs with low plasma taurine were older, less active, had more medical problems and treatments, and had lower plasma albumin, cyst(e)ine, tryptophan, and alpha-amino-n-butyric acid concentrations than the other dogs (P < 0.05). Of 9 taurine-deficient, clinically evaluated dogs, 3 had DCM that was reversed by taurine supplementation and 1 had retinal degeneration. When given a diet apparently adequate in sulfur amino acids (5.4 g/kg) for 3 wk, 6 Newfoundlands (52.5 +/- 2.3 kg, 3.5-7 y), compared with 6 Beagles (13.2 +/- 2.3 kg, 5.5 y), had lower (P < 0.01) concentrations of plasma taurine (49 +/- 16 vs. 97 +/- 25 micromol/L) and cyst(e)ine and blood glutathione, lower (P < 0.01) de novo taurine synthesis (59 +/- 15 vs. 124 +/- 27 mg x kg(-0.75) x d(-1)), and greater (P < 0.05) fecal bile acid excretion (1.7 +/- 0.2 vs. 1.4 +/- 0.2 micromol/g). Newfoundlands would appear to have a higher dietary sulfur amino acid requirement than Beagles, a model breed used in nutrient requirement determinations.

(PDF emailed within 0-6 h: $19.90)

Accession: 013152662

Download citation: RISBibTeXText

PMID: 16988121

DOI: 10.1093/jn/136.10.2525



Related references

Evaluation of taurine status in cats consuming diets containing different amounts of taurine by determination of plasma and whole blood taurine concentrations. Journal of Nutritional Biochemistry 4(3): 168-171, 1993

Platelet taurine concentration can be predicted from whole blood taurine concentrations in dogs. Journal of Nutrition 136(7 Suppl): 2055s-2057s, 2006

Plasma and whole blood taurine concentrations respond differently to taurine supplementation and depletion. Zeitschrift fuer Ernaehrungswissenschaft 34(2): 137-142, 1995

Effect of dietary taurine on plasma and blood cell taurine concentrations in cats. Journal of Nutrition 117(11): 1945-1949, 1987

Evaluating taurine status: determination of plasma and whole blood taurine concentration. Journal of Nutritional Biochemistry 2(10): 571-576, 1991

Effect of dietary intake of taurine and protein on taurine concentration in plasma of the cat. Federation Proceedings 39(3): ABSTRACT 4102, 1980

Plasma and whole blood taurine concentrations respond differently to taurine supplementation (humans) and depletion (cats). Zeitschrift fur Ernahrungswissenschaft 34(2): 137-142, 1995

The effect of dietary taurine content on the plasma taurine concentration of the cat. British Journal of Nutrition 66(2): 227-235, 1991

Release of taurine in brain microdialysates after ethanol injection The influence of plasma taurine concentrations and NMDA receptors. Alcoholism Clinical & Experimental Research 22(3 ABSTR SUPPL ): 175A, 1998

The effect of dietary supplementation with cysteic acid on the plasma taurine concentration of cats maintained on a taurine-restricted diet. Advances in Experimental Medicine and Biology 315: 23-32, 1992

Taurine concentration in the brain and in the plasma following taurine ip injection. Amino Acids (Vienna) 25(2): 189, September, 2003

Influence of taurine intake on plasma taurine values and renal taurine excretion of cats. Journal of Nutrition 121(11 Suppl): S175-S176, 1991

Effect of intravenous taurine supplementation on plasma, blood cell, and urine taurine concentrations in adults undergoing long-term parenteral nutrition. American Journal of Clinical Nutrition 52(5): 846-853, 1990