+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Anticipation of aversive stimuli activates extended amygdala in unipolar depression



Anticipation of aversive stimuli activates extended amygdala in unipolar depression



Journal of Psychiatric Research 41(6): 511-522



According to cognitive theories, negative cognitions including negative attitudes towards the future are key factors associated with depressive disorder. We investigated the neural correlates of anticipation of emotional stimuli in patients with unipolar depression to reveal influences of future thinking on brain activity. We used functional magnetic resonance imaging (fMRI) to study 12 female patients with stable antidepressant medication and 12 healthy women. Subjects were presented with positive, negative and neutral pictures that were announced by a congruent cue. Subjects were instructed to expect and subsequently watch the pictures. After scanning, subjects filled the Emotion Regulation Questionnaire (ERQ) to assess the regulation strategies suppression and reappraisal. Compared to the healthy control group, during expectation of negative vs. neutral or positive stimuli the patients showed significantly more activation within the sublenticular extended dorsal amygdala (SLEA) bilaterally but did not differ from controls upon expecting positive stimuli. Hamilton depression scores of the patients correlated positively with activation of the left and right ventral amygdala during expectation of negative stimuli. Furthermore, we found a negative correlation of ventral amygdala activation in the patients with reappraisal scores comprising the ability to limit emotional responding by re-interpreting emotion-eliciting situations. We interpret enhanced activation in the amygdala/SLEA as a possible consequence of altered future thinking in patients suffering from depression. Supporting cognitive theories, this finding does represent evidence that altered cognitions as potentially involved in expectation result in differences in brain activity.

(PDF emailed within 0-6 h: $19.90)

Accession: 013229104

Download citation: RISBibTeXText

PMID: 17010993

DOI: 10.1016/j.jpsychires.2006.07.020


Related references

Anticipation of emotionally aversive visual stimuli activates right insula. Neuroreport 15(14): 2261-2265, 2004

Direct activation of the ventral striatum in anticipation of aversive stimuli. Neuron 40(6): 1251-1257, 2003

Functional amygdala-hippocampus connectivity during anticipation of aversive events is associated with Gray's trait "sensitivity to punishment". Biological Psychiatry 68(5): 459-464, 2010

Neurons in the macaque anterior cingulate cortex activating during anticipation of aversive stimuli. Neuroscience Research Supplement (22): S203, 1998

Anticipation of aversive visual stimuli is associated with increased insula activation in anxiety-prone subjects. Biological Psychiatry 60(4): 402-409, 2006

Increased anxiety during anticipation of unpredictable but not predictable aversive stimuli as a psychophysiologic marker of panic disorder. American Journal of Psychiatry 165(7): 898-904, 2008

Neurons activated during anticipation of reward or aversive stimuli in the anterior cingulate cortex of macaque monkeys. Neuroscience Research Supplement (24): S115, 2000

Aversive auditory stimuli activate the human amygdala. Society for Neuroscience Abstracts 26(1-2): Abstract No -403 4, 2000

The lateral amygdala processes the value of conditioned and unconditioned aversive stimuli. Neuroscience 133(2): 561-569, 2005

Major depression is not associated with blunting of aversive responses; evidence for enhanced anxious anticipation. Plos One 8(8): E70969, 2014

Role of amygdala in conditioned versus unconditioned responding to aversive stimuli. Society for Neuroscience Abstract Viewer & Itinerary Planner : Abstract No 85 11, 2002

Amygdala activity related to enhanced memory for pleasant and aversive stimuli. Nature Neuroscience 2(3): 289-293, 1999

Amygdala c-Fos induction corresponds to unconditioned and conditioned aversive stimuli but not to freezing. Behavioural Brain Research 152(1): 109-120, 2004

Anticipation-related brain connectivity in bipolar and unipolar depression: a graph theory approach. Brain 139(Pt 9): 2554-2566, 2017

Reduced reward anticipation in youth at high-risk for unipolar depression: a preliminary study. Developmental Cognitive Neuroscience 8: 55-64, 2014