Enantioselective organocatalytic conjugate addition of amines to alpha,beta-unsaturated aldehydes: one-pot asymmetric synthesis of beta-amino acids and 1,3-diamines
Vesely, J.; Ibrahem, I.; Rios, R.; Zhao, G.-Ling; Xu, Y.; Cordova, A.
Tetrahedron Letters 48(12): 2193-2198
2007
ISSN/ISBN: 0040-4039
Accession: 013242476
Organocatalytic asymmetric amine conjugate additions to alpha, beta-unsaturated aldehydes catalyzed by protected diarylprolinols are presented. The reactions proceed with high enantioselectivity and result in Cbz or Boc protected beta-amino aldehydes, gamma-amino alcohols, beta-amino acids and 1,3-diamines with typically 82-99% ee.
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