Expression of CCR5 and CD30 molecules in peripheral blood lymphocytes of patients with autoimmune thyroid disease
Mao-Jin-Yuan; Fan-Chen-Ling; Guan-Hai-Xia; Shan-Zhong-Yan; Li-Yu-Shu; Man-Na; Teng-Wei-Ping
Journal of China Medical University 36(1): 66-68
Objective: To explore the T helper cells (Th1/Th2) bias in autoimmne thyroid disease (AITD) and its effect on the development of AM. Methods: The percentage and mean fluorescence intensity (MR) of CCR5-positive and CD30-positive cells were determined by using flow cytometry in 21 patients with Graves' disease (GD group),21 patients with Hashimoto thyroiditis (HT group),and 45 healthy subjects (control group). Results: Compared with the control group,the percentage of CD30-positive cells significantly increased (P < 0.05) and the MFT of CCR5-positive cells significantly decreased (P < 0.01) in GD group. The percentages of both CCR5-positive and CD30positive cells significantly increased in HT group (P < 0.05). The MFT of CD30-positive cells were positively correlated with the level of thyroid stimulating hormone receptor antibody. Conclusion: GD is a Th2-dominated disease. Both n1 and Th2 cells may be involved in the pathogenesis of HT.