+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

The neuroendocrine impact of chronic stress on cancer



The neuroendocrine impact of chronic stress on cancer



Cell Cycle 6(4): 430-433



Behavioral processes have long been suspected to influence many health processes including effects on cancer. However, mechanisms underlying these observations are not fully understood. Recent work has demonstrated that chronic behavioral stress results in higher levels of tissue catecholamines, greater tumor burden, and a more invasive pattern of ovarian cancer growth in an orthotopic mouse model. These effects are mediated primarily through the beta(2) adrenergic receptor (ADRB2) activation of the tumor cell cyclic AMP (cAMP)-protein kinase A (PKA) signaling pathway. Additionally, tumors in stressed animals have increased vascularization and enhanced expression of vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs) -2 and -9. In this review, we highlight the importance of the neuroendocrine stress response in tumor biology and discuss mechanisms by which the beta-adrenergic receptors on ovarian cancer cells enhance angiogenesis and tumor growth.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 013273651

Download citation: RISBibTeXText

PMID: 17312398

DOI: 10.4161/cc.6.4.3829


Related references

Chronic stress influences cardiovascular and neuroendocrine responses during acute stress and recovery, especially in men. Health Psychology 20(6): 403-410, 2001

Prolonged alterations in neuroendocrine responses to acute stress following chronic variable stress. Society for Neuroscience Abstract Viewer & Itinerary Planner : Abstract No 614 11, 2003

Neuroendocrine correlates of chronic stress the activity stress paradigm. Neuroendocrinology Letters: 175, 1987

Long-term behavioral and neuroendocrine alterations following chronic social stress in mice: implications for stress-related disorders. Hormones and Behavior 53(2): 386-394, 2007

Effects of chronic social stress in adolescence on anxiety and neuroendocrine response to mild stress in male and female rats. Behavioural Brain Research 187(2): 228-238, 2007

Effects of chronic cold exposure on brain noradrenergic and neuroendocrine stress reactivity in rat strains differing in their basal stress response. Society for Neuroscience Abstracts 27(2): 2350, 2001

Chronic psychological stress and its impact on the development of aggressive breast cancer. Einstein 13(3): 352-356, 2016

Impact of prenatal stress on neuroendocrine programming. Thescientificworldjournal 7: 1493-1537, 2007

Impact of aging on stress-responsive neuroendocrine systems. Mechanisms of Ageing & Development 122(9): 963-983, 15 July, 2001

Neuroendocrine function and chronic inflammatory stress. Pfluegers Archiv European Journal of Physiology 443(Supplement 1): S381, March, 2002

Neuroendocrine mechanisms of impact by experimental stress on plasma glucose level in STZ KM mice. Zhonghua Yi Xue Za Zhi 79(5): 332-334, 2001

L-tyrosine improves neuroendocrine function in a mouse model of chronic stress. Neural Regeneration Research 7(18): 1413-1419, 2012

Reversal of neuroendocrine effects of chronic stress by the transcendental meditation technique. Society for Neuroscience Abstracts 21(1-3): 1389, 1995

Neuroendocrine and immunological correlates of chronic stress in 'strictly healthy' populations. Neuroimmunomodulation 17(1): 9-18, 2010

Adaptation to chronic stress. Temporal pattern of immune and neuroendocrine correlates. Neuropsychopharmacology 1(3): 239-242, 1988