A comparison of the influence of a high-fat diet enriched in monounsaturated fatty acids and conventional diet on weight loss and metabolic parameters in obese non-diabetic and Type 2 diabetic patients

Brunerova, L.; Smejkalova, V.; Potockova, J.; Andel, M.

Diabetic Medicine a Journal of the British Diabetic Association 24(5): 533-540

2007


ISSN/ISBN: 0742-3071
PMID: 17381504
DOI: 10.1111/j.1464-5491.2007.02104.x
Accession: 013286673

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Abstract
Aims: The aim of our study was to compare the influence of a hypocaloric, high-fat diet enriched with MUFA (M) and conventional diet (C) on weight loss and metabolic parameters in obese non-diabetic and obese Type 2 diabetic subjects over a 3-month period. It was our hypothesis that the enriched diet would be more effective in decreasing blood glucose and glycated haemoglobin (HbA1c) than the control diet. Methods: Twenty-seven Type 2 diabetic patients (54.5+or-3.5 years; DM), treated with diet or oral glucose-lowering agents, and 31 obese non-diabetic subjects (53.6+or-3.5 years; OB) were randomized to M or C. Individual calculations of energy requirements were based on the formula: [resting energy expenditure (REE) x 1.5]-600 kcal. Subjects were assessed by a dietitian every 2 weeks and by a physician every month. Statistical analyses were carried out between the four groups - DM/M, DM/C, OB/M and OB/C - using pair Student's test and ANOVA. Results: After 3 months, body weight, waist-hip ratio, total body fat, levels of C-peptide, triglycerides and homeostasis model assessment (HOMA) decreased in all four groups (P<0.01). However, fasting blood glucose and HbA1c decreased (P<0.01) and high-density lipoprotein cholesterol increased significantly only in the DM/M group (P<0.05). In general, M was well tolerated. Conclusions: Individualized M and C diets were successful in improving metabolic and anthropometric parameters in both the obese non-diabetic and the Type 2 diabetic subjects. Although the superiority of the higher fat diet did not reach statistical significance, the decline in blood glucose and HbA1c in the Type 2 diabetic group on M was encouraging.

A comparison of the influence of a high-fat diet enriched in monounsaturated fatty acids and conventional diet on weight loss and metabolic parameters in obese non-diabetic and Type 2 diabetic patients