Calcification and ossification. 2. Control of calcification in the fracture callus in rachitic rats
Urist, M.R.; Mclean, F.C.
J. Bone Joint Surg 23: 283-310
The healing of fractures in rats rendered rachitic by a diet low in P was delayed from the 5th day onwards, with diminished invasion of the callus by osteoid tissue and excessive formation of fibrous tissue and fibrocartilage. The administration of P or vitamin D promoted calcification, but since this only took place where the cartilage was in contact with periosteum or advancing subperiosteal bone, the disordered structure of the callus led to delayed calcification.