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Effects of Extract of Cattle Ant. Pituitary on Endo-chondral Ossification in Thyroideetomized Young Guinea Pigs



Effects of Extract of Cattle Ant. Pituitary on Endo-chondral Ossification in Thyroideetomized Young Guinea Pigs



Proc. Soc. exp. Biol, N.Y., 33: 554-558



The author studied the influence of an acid extract of the anterior pituitary gland of cattle on the growth of bone and cartilage in thyroidectomized young guineapigs. He found that it caused a hypertrophy and hyperplasia of the different cell layers of the chondrophyte and epiphyseal line with subsequent rapid calcification and premature closure of the latter. He concluded that anterior pituitary extract exerts its influence on bone and cartilage without the mediation of the thyroid gland.

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