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Studies in the secretion o! milk fat. 1. The effect of inanition on the blood lipoids of the lactating cow



Studies in the secretion o! milk fat. 1. The effect of inanition on the blood lipoids of the lactating cow



Biochem. J 32: 1856-1867



This work was carried out on 3 non-pregnant Ayrshire cows in the 6th to 7th month of lactation. After a few weeks on a normal, well balanced ration, food was withheld from 2 of them for 12 days, alter which they were again fed. Water was given freely at all tunes. One of the 2 cows developed milk fever on the 2nd day of the fast, but the symptoms disappeared after inflation of the udder. The other cow remained normal. In the case of the third cow the experiment was stopped on the 7th day of the fast owing to the unsatisfactory condition of the animal. At intervals before, during, and after the fast, blood samples were drawn from a mammary vein and the plasma and corpuscles were separated and the lipoid content determined. In the corpuscles only a very slight decrease, less than 10 per cent., was observed in the lipoid P levels and after refeeding for a. few weeks the values tended to return to their original level. In the plasma much greater changes were observed. The mean initial values were reduced by about 40 per cent, during inanition and the low levels persisted even for 6 weeks after free access to food. There was no evidence of any alteration in the nature. of the corpuscle lipoids during prolonged inanition. In the cow which remained normal during inanition the plasma ester cholesterol, nonphosphatide fatty acids and phosphatide fatty acids all fell markedly during inanition and they showed a further more or less marked fall during the first days of refeeding. In the cow which developed milk fever this was accompanied by hyperlipaemia, but after the symptoms of milk fever had subsided the changes in blood lipoids were similar to those in the first cow. There was a marked tendency for the various lipoid constituents of the plasma, with the possible exception of the triglycerides, to behave alike under different conditions, thus resulting in a tendency for a constant composition of the lipoids. As in the corpuscles so in the plasma no appreciable change could be detected in the actual nature of the lipoids as a result of inanition, although there appeared to be a greater degree of unsaturation in the fattyacids during milk fever. The data suggest that if any water soluble fatty acids are present in the non-phosphatide fraction of the plasma, their actual amount must be exceedingly small. (See Abst, 2921, Vol. 8.)-W. Godden.

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Accession: 013512198

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PMID: 16746820


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