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The effect of administration of iodine on the total iodine, inorganic iodine, and thyroxine content of the pathological thyroid gland



The effect of administration of iodine on the total iodine, inorganic iodine, and thyroxine content of the pathological thyroid gland



Jour Biol Chem 97(1): 303-324



A procedure for the partition of the known I compounds of the thyroid gland is described, based on the method of Leland and Foster for the determination of thyroxine, a slightly modified Kendall method for determination of total I, and aqueous extraction of the desiccated gland for estimation of inorganic I. The data derived by this procedure on 117 pathological thyroid glands obtained after thyroidectomy, and on 20 normal glands are presented. Comparison of the results on 70 thyroid glands of patients with exophthalmic goiter who had received I, with the data in the literature on thyroid glands of untreated patients with exophthalmic goiter suggests the following changes as a result of I administration: (1) an increase in the total I content of the gland, due to an increase in both inorganic I and thyroglobulin I fractions; (2) a change in the chemical nature of the thyroglobulin as evidenced by (a) an increase in the thyroxine I per cent of thyroglobulin iodine and (b) a consequent decrease in the per cent of thyroglobulin I not in the form of thyroxine, but chiefly or entirely as diiodotyrosine; (3) an increase in the relative and absolute thyroxine and diiodotyrosine content of the gland. Comparison with the data on normal glands suggests that these changes constitute a return from the more or less depleted state of the untreated exophthalmic gland toward that of the resting gland. The physiological significance of the changes in the content and distribution of I in the pathological thyroid gland is briefly discussed.

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