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Certain aspects of the pharmacology of the salicylates


, : Certain aspects of the pharmacology of the salicylates. Pharmacol. Rev, 1: 353-382

Salicylates are rapidly absorbed from all portions of the gastrointestinal tract, absorption being most rapid in the small intestine from slightly acid solutions. Distribution is throughout the body, appreciable amounts being within the cells. Degradation includes partial oxidation or conjugation with glycine or glycuronic acid. Excretion is moderately rapid, the free salicylate being excreted more rapidly when the urinary pH is high.

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