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Certain aspects of the pharmacology of the salicylates

, : Certain aspects of the pharmacology of the salicylates. Pharmacol. Rev, 1: 353-382

Salicylates are rapidly absorbed from all portions of the gastrointestinal tract, absorption being most rapid in the small intestine from slightly acid solutions. Distribution is throughout the body, appreciable amounts being within the cells. Degradation includes partial oxidation or conjugation with glycine or glycuronic acid. Excretion is moderately rapid, the free salicylate being excreted more rapidly when the urinary pH is high.

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Related references

Smith, P.K., 2014: Certain aspects of the pharmacology of the salicylates. Pharmacological Reviews 1(3): 353-382

Anonymous, 1969: The clinical pharmacology of salicylates. These discussions are selected from the weekly staff conferences in the Department of Medicine, University of California Medical Center, San Francisco. Taken from transcriptions, they are prepared by Drs. Martin J. Cline and Hibbard E. Williams, A...

Smith, P.K.; Gleason, H.L., 1946: Studies on the pharmacology of salicylates. Colorimetric methods have been developed for the detn. in urine of free salicylate, salicyluric acid and total salicylates. Most of the salicylate in human plasma is bound to the non-diffusible components, presumably plasma proteins. Even at high...

Davis, L.E., 1980: Clinical pharmacology of salicylates. Journal of the American Veterinary Medical Association 176(1): 65-66

Smith, P.K., 1960: The pharmacology of salicylates and related compounds. Salicylates act as antipyretic agents chiefly by increasing heat dissipation through cutaneous vasodilatation. Very large doses may have the opposite effect of raising body temperature. The site of the analgesic action has not been defined precise...

Smith, M.J.H., 1953: Some recent advances in the pharmacology of salicylates. Journal of Pharmacy and Pharmacology 5(2): 81-93

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Buchanec, J.; Visnovský, P.; Galanda, V.; Pullmann, R.; Visnovská, B., 1982: Pharmacology of salicylates in children. VII. Effect on the acid-base equilibrium. Ceskoslovenska Pediatrie 37(5): 266-268

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Kleinerman, E.S.; Louie, J.S.; Wahl, L.M.; Muchmore, A.V., 1981: Pharmacology of human spontaneous monocyte-mediated cytotoxicity. I. Enhancement by salicylates and steroids. The effect of various antiinflammatory agents on the spontaneous cytotoxicity of human mononuclear cells in vitro was assessed. Acetylsalicylic acid (ASA) and hydrocortisone enhanced spontaneous monocyte-mediated cytotoxicity compared to control v...