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Essais de traitement de la filarios a Wuchereria bancrofti var. pacifica par le i-diethyl carbamyl, 4-methyl piperazine, a Tahiti



Essais de traitement de la filarios a Wuchereria bancrofti var. pacifica par le i-diethyl carbamyl, 4-methyl piperazine, a Tahiti



Bulletin de la Societe de Pathologie Exotique 42(5/6): 304-313



Galliard & Mille report upon the action of hetrazan on Wuchereria bancrofti var. pacifica in Tahiti. In doses of 2 mg. per kg. body-weight three times a day there is a rapid disappearance of microfilariae in from 48 hours to 7 days. Relapses, light in nature, occur in 40% of cases where the dosage has been insufficient. More important is the occurrence of 14% of relapses four months after a single treatment, but as the microfilariae are not rendered resistant subsequent treatment is effective.

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