+ Site Statistics
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Heat shock transcription factors regulate heat induced cell death in a rat histiocytoma

, : Heat shock transcription factors regulate heat induced cell death in a rat histiocytoma. Journal of Biosciences 32(3): 585-593

Heat shock response is associated with the synthesis of heat shock proteins (Hsps) which is strictly regulated by different members of heat shock transcription factors (HSFs). We previously reported that a rat histiocytoma, BC-8 failed to synthesize Hsps when subjected to typical heat shock conditions (42 degrees C, 60 min). The lack of Hsp synthesis in these cells was due to a failure in HSFI DNA binding activity. In the present study we report that BC-8 tumor cells when subjected to heat shock at higher temperature (43 degrees C, 60 min) or incubation for longer time at 42 degrees C, exhibited necrosis characteristics; however, under mild heat shock (42 degrees C, 30 min) conditions cells showed activation of autophagy. Mild heat shock treatment induced proteolysis of HSF1, and under similar conditions we observed an increase in HSF2 expression followed by its enhanced DNA binding activity. Inhibiting HSF 1 proteolysis by reversible proteasome inhibition failed to inhibit heat shock induced autophagy. Compromising HSF2 expression but not HSF 1 resulted in the inhibition of autophagy, suggesting HSF2 dependent activation of autophagy. We are reporting for the first time that HSF2 is heat inducible and functions in heat shock induced autophagic cell death in BC-8 tumor cells.

(PDF same-day service: $19.90)

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 013726480

PMID: 17536178

DOI: 10.1007/s12038-007-0058-4

PDF Full Text: Submit

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Banks, C. H., 1961: The hydrological effects of riparian and adjoining vegetation. The experimental treatments applied in the main and supplementary potamological investigations at Jonkershoek are briefly discussed. The paper describes how the main experiment, although not specifically designed to test the effect of altering the...

Alves, A. M. B.; Lasaro, M. O.; Almeida, D. F.; Armoa, G. R. G.; Ferreira, L. C. S., 1999: DNA immunization against ETEC CFA/I fimbriae based on three different plasmid constructions. Abstracts of the General Meeting of the American Society for Microbiology 99: 291

Devadas, V. S.; Rani, T. G.; Kuriakose, K. J.; Seena, P. G.; Gopalakrishnan, T. R., 1998: Effect of fruit grading on seed quality in snakegourd (Trichosanthes anguina L.). The effect of fruit size (large, medium or small with lengths of 100-130, 75-95 and 50-80 cm, respectively) on seed quality (assessed as seed size, percentage germination and seedling vigour) was investigated in T. anguina [T. cucumerina] cv. Kaum...

Chen, W.; Srinivasan, S. R.; Berenson, G. S., 2008: An elevation of white blood cells is associated with metabolic syndrome in black and white children and adults: The Bogalusa heart study. Journal of Investigative Medicine 56(1): 432

Green, Jl, 1981: Autumn Blaze: new Callery pear introduction from Oregon State University. Ornamentals northwest newsletter Cooperative Extension Service Oregon State Univeristy 5(5): 14-15

Artun, E.; Ertekin, T.; Watson, R.; Miller, B., 2012: Designing cyclic pressure pulsing in naturally fractured reservoirs using an inverse looking recurrent neural network. In this paper, an inverse looking approach is presented to efficiently design cyclic pressure pulsing (huff 'n' puff) with N2 and CO2 , which is an effective improved oil recovery method in naturally fractured reservoirs. A numerical flo...

Krull, W., 1937: Rearing Aquatic snails. Galtsoff. Culture Methods for Invertebrate Animals. Unknown

Kanasewich E. R.; Burianyk M. J. A., 1994: Velocity structure of the southeastern Cordillera in British Columbia. Seismological Research Letters 65(1): 16

Cortes, N. J.., 1986: Biogeografia de corales hermatipicos el istmo Centro Americano. Anales del Instituto de Ciencias del Mar y Limnologia Universidad Nacional Autonoma de Mexico, 131: 297-304

Singh R.K.; Chowdhury A.; Sani B.P., 1990: Detection of cellular retinoic acid binding protein in chick embryonic tissues by monoclonal antibodies. We describe the production of monoclonal antibodies (MAbs) directed against cellular retinoic acid-binding protein (CRABP) and their application for the quantitation and localiation of CRABP during the development and growth of chick embryo. Three...