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Immunologic studies with Malleomyces mallei and Malleomyces pseudomallei. II. Agglutination and complement fixation tests in man and laboratory animals



Immunologic studies with Malleomyces mallei and Malleomyces pseudomallei. II. Agglutination and complement fixation tests in man and laboratory animals



Jour Infect Dis 86(1): 52-62



Agglutination and complement-fixation tests for glanders and melioidosis were performed with 400 samples of normal human sera, and with 150 samples of sera from patients with brucellosis, tularemia, anthrax, atypical pneumonia and infectious mononucleosis. The agglutination titers ranged from 1:10 to 1:320. The complement-fixation test was negative with all sera at a dilution of 1:10. It was also shown that most normal laboratory animals have agglutinins in low titer for both M. mallei and M. pseudomallei. Infected laboratory animals developed agglutinins and complement-fixing antibodies in high titer. The agglutination and complement-fixation tests were vital in making the diagnosis of 6 human laboratory infections with M. mallei. The peak agglutination titer in human cases was 1:2560, and the highest complement-fixation titer observed in human infection was 1:640.

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Accession: 013733173

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PMID: 15402291

DOI: 10.1093/infdis/86.1.52


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