+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

More than one door - Budding of enveloped viruses through cellular membranes

More than one door - Budding of enveloped viruses through cellular membranes

Febs Letters 581(11): 2089-2097

Enveloped viruses exit their host cell by budding from a cellular membrane and thereby spread from one cell to another. Virus budding in general involves the distortion of a cellular membrane away from the cytoplasm, envelopment of the viral capsid by one or more lipid bilayers that are enriched in viral membrane glycoproteins, and a fission event that separates the enveloped virion from the cellular membrane. While it was initially thought that virus budding is always driven by viral transmembrane proteins interacting with the inner structural proteins, it is now clear that the driving force may be different depending on the virus. Research over the past years has shown that viral components specifically interact with host cell lipids and proteins, thereby adopting cellular functions and pathways to facilitate virus release. This review summarizes the current knowledge of the cellular membrane systems that serve as viral budding sites and of the viral and cellular factors involved in budding. One of the best studied cellular machineries required for virus egress is the ESCRT complex, which will be described in more detail.

(PDF emailed within 0-6 h: $19.90)

Accession: 013763717

Download citation: RISBibTeXText

PMID: 17434167

DOI: 10.1016/j.febslet.2007.03.060

Related references

Cellular ESCRT complex and its roles in enveloped viruses budding. Sheng Wu Gong Cheng Xue Bao 28(9): 1031-1037, 2013

Budding of enveloped viruses from the plasma membrane. Bioessays 19(11): 993-1000, 1997

The budding mechanisms of enveloped animal viruses. Journal of General Virology 50(1): 1-21, 1980

Mechanisms for enveloped virus budding: can some viruses do without an ESCRT?. Virology 372(2): 221-232, 2007

Heterogeneous progeny viruses are produced by a budding enveloped phage. Intervirology 23(4): 208-221, 1985

Why Enveloped Viruses Need Cores-The Contribution of a Nucleocapsid Core to Viral Budding. Biophysical Journal 114(3): 619-630, 2018

Why Enveloped Viruses Need CoresThe Contribution of a Nucleocapsid Core to Viral Budding. Biophysical Journal 114(3): 619-630, 2018

Budding of Enveloped Viruses: Interferon-Induced ISG15-Antivirus Mechanisms Targeting the Release Process. Advances in Virology 2012: 532723-532723, 2012

Interaction of enveloped viruses with planar bilayer membranes: observations on Sendai, influenza, vesicular stomatitis, and Semliki Forest viruses. Virology 128(1): 186-194, 1983

Polarization of islet cells evidence from asymmetric budding of enveloped viruses in monolayer cultures of endocrine pancreas. Diabetologia 27(2): 304A-305A, 1984

Viral membranes: an emerging antiviral target for enveloped viruses?. Expert Review of Anti-Infective Therapy 8(6): 635-638, 2010

The biology and biochemistry of cellular receptors for enveloped viruses. Receptors and recognition Series B(2): 85-115, 1981

Fusion of enveloped viruses with biological membranes. Fluorescence dequenching studies. Sub-Cellular Biochemistry 13: 415-456, 1988

Entry mechanisms of enveloped viruses. Implications for fusion of intracellular membranes. Bioscience Reports 9(3): 273-305, 1989

Plunder and stowaways: incorporation of cellular proteins by enveloped viruses. Journal of Virology 79(11): 6577-6587, 2005