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Prevention of thiouracil goitre in tile rat by means of vitamin A methyl ether

Prevention of thiouracil goitre in tile rat by means of vitamin A methyl ether

Experientia 4: 232-233

It was sought by experiments with rats to find some means of combating the increased circulatory flow to the thyroid gland and the ensuing fragility of the blood vessels, which make a difficulty for surgeons in patients treated with thiouracil. Groups of 7 to 10 young female rats of 30 to 40 g. weight were given, for 7 to 10 days, daily doses per kg. bodyweight of 0.1 to 0.05 g. of 2-thio-6-methyluracil, with or without daily administration of 20, 000 I.U. vitamin A methyl ether.

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