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Studies on the mechanism of action of ionizing radiations. VI. The oxidation of thiols by ionizing radiations



Studies on the mechanism of action of ionizing radiations. VI. The oxidation of thiols by ionizing radiations



Jour Gen Physiol 33(3): 229-241



Thiol compounds, such as glutathione, 2,3-dimercaptopropanol (BAL), propane-l,3-dithiol, and N-phenylaminopropanedithiol, were readily oxidized by X-rays, beta rays, and gamma rays. The ionic yield for this oxidation was about the same, 3 at pH 7, on irradiation with X-rays and with beta rays; it was 23% less on irradiation with gamma rays. The ionic yield varied with the pH, increasing as the pH value increased. There was no reduction of oxidized glutathione on irradiation with dosages of X-rays and gamma rays which produced oxidation of the reduced compound. In the absence of oxygen, the oxidation of thiols by ionizing radiations was only 33% of that obtained in the presence of dissolved oxygen. When the thiol solns. were irradiated in the presence of dissolved oxygen, catalase protected them from oxidation by 17-27%.

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Accession: 013845061

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DOI: 10.1085/jgp.33.3.229


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