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Absorption of sugars and amino acids from isolated surviving intestine after experimental shock



Absorption of sugars and amino acids from isolated surviving intestine after experimental shock



Archives of Biochemistry and Biophysics 62(2): 485-496



The rate of absorption of glucose, DL-alanine, D- and L-leucine and L-glutamine by the isolated surviving guinea pig small intestine, obtained from animals that have succumbed to experimental (tourniquet) shock were below normal. Conversion of fructose into glucose in intestine after experimental shock was abolished. Thus fructose diffusion per se appeared to be unaffected, but the total amount of sugar (glucose and fructose) absorbed by the intestine in the presence of fructose was diminished by shock. The rate of absorption of sorbose was unaffected by shock. The metabolic conditions produced in the isolated intestine by shock, resembled those in normal intestine under anaerobiosis. Asphyxia did not affect glucose absorption by the isolated intestine Ligation of the blood vessels supplying a segment of the intestine terminated active absorption of glucose by that segment of intestine. During experimental shock anoxia develops in the intestine and "active" absorption of glucose, fructose and amino acids is terminated.

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Accession: 013945894

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PMID: 13328137

DOI: 10.1016/0003-9861(56)90147-3


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