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Adaptation in pantothenate-requiring Neurospora. I. A gene modifying pantothenate mutants

Adaptation in pantothenate-requiring Neurospora. I. A gene modifying pantothenate mutants

Amer Jour Bot 47(5): 351-357

A modified pantothenicless strain was isolated from a pan-1, al-1, A mycelium which had adapted to a limiting concentration of pantothenate. The modified and original strains differ by a single gene, m, which is not linked genetically to either of the 2 known pantothenic acid loci. The gene m appears to modify the uptake, rather than the synthesis, of pantothenate on the part of both pan-1 and pan-2 mutants. Neither pan mutant in combination with m grows on minimal medium. However, the pan-1 m and pan-2 m strains grow to a greater extent than pan-1 or pan-2 in limiting pantothenate concentrations. The mechanism of action of the m gene is discussed, and compared to modifiers of certain other mutant phenotypes of Neurospora.

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Accession: 013947792

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DOI: 10.2307/2439222

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