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Deposition of fluoride, calcium and phosphorus in experimental low-phosphorus rickets



Deposition of fluoride, calcium and phosphorus in experimental low-phosphorus rickets



Journal of Nutrition 67(1): 59-68



Rats were rendered rachitic on a diet adequate in vitamins A and D and in Ca but markedly deficient in P. Litter-mate rats received the same diet supplemented with Na2HPO4. An equalized intake of fluoride was provided by the drinking water. Ash, fat, F-, Ca and P were determined in femurs, mandibles, molar and incisor teeth. The bones of the rachitic rats showed a marked reduction in ash, whereas the teeth were essentially normal. The bones of the rachitic rats also contained less Ca but more P, resulting in a highly significant reduction in the Ca/P ratio. There was no change in the Ca or P concentration of the teeth of rachitic rats, nor in the Ca, P or Ca/P ratio in the bones and teeth of the non-rachitic pair-fed and ad libitum-fed rats. The femur and mandible ash of the rachitic rats was increased two and one-half times in F- content as compared with the bone ash of non-rachitic litter mates. However, markedly less total F- was present in the rachitic bones. Fluoride in the teeth was not altered by the rachitic state of the animals. The data permitted the conclusion that the observed changes in the rachitic rats were due to the extremely low P content of the diet rather than to inanition.

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Accession: 014006854

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PMID: 13631515



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