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Effect of saturated and unsaturated fats on the concentration of serum cholesterol and experimental atherosclerosis


Effect of saturated and unsaturated fats on the concentration of serum cholesterol and experimental atherosclerosis



Circulation Research 7(3): 448-453



ISSN/ISBN: 0009-7330

PMID: 13652395

DOI: 10.1161/01.res.7.3.448

The feeding of a diet containing 12% safflower oil to rabbits fed for approximately 125 days did not significantly alter the serum cholesterol levels from the pre-experimental concentrations. The substitution of coconut oil in a 2d group of rabbits resulted in a twofold increase in serum cholesterol at the end of the experiment. The addition of either safflower or coconut oils to a diet containing 0.5% cholesterol caused a threefold higher average serum concentration than did the feeding of cholesterol alone. Post-mortem examination of rabbits failed to reveal experimental atherosclerosis in groups fed safflower or coconut oil (without cholesterol). Sixty-three percent of the cholesterol fed control animals had visible atheromatous lesions. If the safflower or coconut oils were added to the diet containing 0.5% cholesterol, the occurrence of lesions was slightly greater than in the animals on cholesterol alone. However, this difference was not statistically significant. In the present study, the addition of safflower oil rich in unsaturated fatty acids failed to prevent the hypercholesteremia and experimental atherosclerosis in cholesterol-fed rabbits.

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Accession: 014025639

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