Effect of saturated and unsaturated fatty acids on dietary lipogranuloma
Herting, D.C.; Harris, P.L.; Crain, R.C.
Journal of Nutrition 70(2): 247-251
Occurrence of lipogranuloma, a foreign-body type reaction in adipose tissue, has been studied in rats fed diets containing ratios of unsaturated to saturated fatty acid ranging fron zero (diet containing only saturated fat as acetylated monoglycerides made from hydrogenated lard) to 3.0 (diet containing a mixture of equal parts of corn oil and lard). The earliest observed occurrence of lipogranuloma was at 2 weeks, on the diet containing completely saturated fat. Fat-cell reaction did not appear to a significant degree when the ratio of unsaturated to saturated fatty acid was 1.0 or greater, but it increased in incidence and severity as the ratio decreased below 1.0.