Effects of anterior pituitary hormones on glucose metabolism by rat mammary gland in vitro

Weinberg, A.N.; Pastan, I.; Williams, H.E.; Field, J.B.

Journal of Biological Chemistry 236: 1002-1005


ISSN/ISBN: 0021-9258
PMID: 13783871
Accession: 014029106

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Prolactin, adrenocorticotropin (ACTH), and growth hormone (GH), in concentration, as low as 5 μg or 0.005 units, caused an increase in glucose uptake and oxidation by rat mammary gland slices in vitro. Stimulation of glucose 1 C14 oxidation by all 3 hormones was noted during gestation, and this effect increased to a maximum in late lactation (15-21 days), and then disappeared with weaning. Oxidation of glucose 6 C14 was increased by all 3 hormones during gestation, early lactation, and after weaning, but towards late lactation only ACTH and GH were active. Evidence is presented indicating that these results are specific for mammary tissue, and not due to contamination with adipose tissue. Thyrotropin, follicle stimulat-ing hormone, and luteinizing hormone did not affect glucose metabolism of mammary tissue.