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Inheritance of susceptibility to Friend mouse leukemia virus



Inheritance of susceptibility to Friend mouse leukemia virus



Japanese Journal of Experimental Medicine 32: 405-413



Susceptibility of mice to the Friend virus was studied by crossing susceptible RF mice with resistant C57BL/6 mice. Spleen enlargement and increase in nucleated blood cell number after virus inoculation were taken as the criterion for infection. All F1, all of the backcross to RF, about half of the backcross to C57BL/6 and about three quarters of F2 mice were susceptible to the virus. These results indicate that the susceptibility is dependent mainly on a single dominant gene. Neither sex nor hair color have any relation to the susceptibility.

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Accession: 014082555

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PMID: 13939449

DOI: 10.1111/j.1440-1827.1968.tb00061.x


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