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Inhibition of COX-2 does not affect therapeutical result of photodynamic therapy with hypericin despite of its increased activity and expression

Inhibition of COX-2 does not affect therapeutical result of photodynamic therapy with hypericin despite of its increased activity and expression

Folia Veterinaria 50(3 Suppl.): 26-27

A photodynamic therapy (PDT) is a multifarious therapeutical approach based on administration of photosensitizer and light dose of appropriate wavelength. PDT with hypericin activates p38 MAPK signalling pathway which induces expression of COX-2 and thereby increases concentration of its main product, PGE2, which is considered as contradictory to photocytotoxic effect and in efficacy of PDT with hypericin.

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