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Inhibition of D-amino acid oxidase by thiamine and thiamine diphosphate



Inhibition of D-amino acid oxidase by thiamine and thiamine diphosphate



Journal of Vitaminology 6: 103-108



Thiamine and TDP inhibited D-amino acid oxidase of hog kidney. The inhibitory action of thiamine was stronger than that of TDP. The type of the inhibition was an intermediate form between competitive inhibition with either flavin adenine dinucleotide (FAD) or D-alanine and non-competitive one. As the mechanism of the increased excretion of riboflavin in urine following administration of large amounts of thiamine, a possibility that binding of thiamine or TDP to flavin-enzyme might result in the release of FAD was suggested.

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Accession: 014082770

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PMID: 14425905


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