+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Inhibition of Histoplasma capsulatum and Blastomyces dermatitidis by Pseudomonas aeruginosa in vitro



Inhibition of Histoplasma capsulatum and Blastomyces dermatitidis by Pseudomonas aeruginosa in vitro



Mycopathologia et Mycologia Applicata 11: 128-134



It was accidentally discovered that P aeruginosa inhibited the growth of H capsulatum when both of the organisms were isolated from a series of sputum specimens obtained from a single patient. Various other pulmonary or systemic fungi were inoculated on blood agar slants and the slants were then superinoculated with P aeruginosa B dermatitidis was inhibited under these conditions, but Cryptococcus neoformans, Sporotrichum schenckii, Geotrichum candidum and Candida albicans were not. Three fractions were obtained from a broth culture of P aeruginosa and their antibiotic effects tested against various systemic fungi and bacteria. Except for a slight inhibition of the H capsulatum, none of the fungi or bacteria tested were inhibited by a concentration of 4-2.5 ml of the fraction of pyocyanin solution per ml of media. The growth of H capsulatum was completely inhibited by concentrations of 4-7 Gm (61 ug) and 4-6 Gm of a chloroform extracted (alpha-oxyphenazine containing) fraction and an oily, ether extracted fraction respectively per ml of media. There was also partial inhibition of this fungus at the next higher dilution (1/4 the concentration). The growth of B dermatitidis was also inhibited by the latter 2 fractions, but at lower dilutions. Other fungi and bacteria tested against the latter 2 fractions were not susceptible to the lowest dilution (4-4 Gm/ml).

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 014082780

Download citation: RISBibTeXText

PMID: 13821877


Related references

In vitro activity of voriconazole against Blastomyces dermatitidis, Coccidioides immitis, and Histoplasma capsulatum. Abstracts of the Interscience Conference on Antimicrobial Agents & Chemotherapy 39: 569, 1999

In vitro activities of voriconazole, itraconazole, and amphotericin B against Blastomyces dermatitidis, Coccidioides immitis, and Histoplasma capsulatum. Antimicrobial Agents and ChemoTherapy 44(6): 1734-1736, 2000

Chemical and immunological properties of galactomannans obtained from Histoplasma duboisii, Histoplasma capsulatum, Paracoccidioides brasiliensis and Blastomyces dermatitidis. Mycopathologia et Mycologia Applicata 54(1): 111-125, 1974

Dimorphism in Histoplasma capsulatum and Blastomyces dermatitidis. Contributions to Microbiology 5: 201-216, 2000

Glucanase production by histoplasma capsulatum and blastomyces dermatitidis. Abstracts of the Annual Meeting of the American Society for Microbiology 76: F25, 1976

Simultaneous infection in man by Histoplasma capsulatum and Blastomyces dermatitidis. American Journal of Medicine 32: 476-489, 1962

Dual Infection with Blastomyces Dermatitidis and Histoplasma Capsulatum. American Journal of Clinical Pathology 23(9): 904-913, 1953

Concurrent Infection with Histoplasma Capsulatum and Blastomyces Dermatitidis. New England Journal of Medicine 270: 874-877, 1964

Electronmicroscopy of self-parasitism by Histoplasma capsulatum and Blastomyces dermatitidis. Mycopathologia et Mycologia Applicata 40(3): 271-276, 1970

Case 49-1988: Histoplasma capsulatum or Blastomyces dermatitidis?. New England Journal of Medicine 320(25): 1699-1700, 1989

Histoplasma capsulatum and Blastomyces dermatitidis as opportunists in human beings. Opportunistic fungal infections Proceedings of the Second International Conference: 215-220, 1975

The readily extracted lipids of Histoplasma capsulatum and Blastomyces dermatitidis. Biochimica et Biophysica Acta 231(3): 465-478, 1971

Frequency of isolation of Histoplasma capsulatum and Blastomyces dermatitidis from dogs in Kentucky. American Journal of Veterinary Research 33(1): 137-141, 1972

Preliminary studies on conidial liberation of Blastomyces dermatitidis and Histoplasma capsulatum. Sabouraudia 14(2): 199-204, 1976

Identification of nonviable cultures of blastomyces dermatitidis and histoplasma capsulatum by their exo antigen. Abstracts of the Annual Meeting of the American Society for Microbiology 82: ABSTRACT F52, 1982