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Inhibition of cholesterol synthesis with the use of Mer-29

Inhibition of cholesterol synthesis with the use of Mer-29

Archives of Internal Medicine 104: 527-531

Forty-one patients with levels of cholesterol above 250 mg. per 100 ml. serum were given daily for periods of up to 15 weeks from 100 to 1000 mg. of a synthetic compound, Mer-29, known to inhibit cholesterol synthesis in rats. Cholesterol was estimated at intervals of one or two weeks. A preliminary report is presented of changes in the levels in 36 patients during 4 weeks of administration of 250 to 1000 mg. Mer-29 daily.

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Accession: 014082818

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PMID: 14428135

DOI: 10.1001/archinte.1959.00270100013003

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