Inhibition of cholesterol synthesis with the use of Mer-29
Inhibition of cholesterol synthesis with the use of Mer-29
Oaks, W.; Lisan, P.; Moyer, J.M.
Archives of Internal Medicine 104: 527-531
1959
Forty-one patients with levels of cholesterol above 250 mg. per 100 ml. serum were given daily for periods of up to 15 weeks from 100 to 1000 mg. of a synthetic compound, Mer-29, known to inhibit cholesterol synthesis in rats. Cholesterol was estimated at intervals of one or two weeks. A preliminary report is presented of changes in the levels in 36 patients during 4 weeks of administration of 250 to 1000 mg. Mer-29 daily.