+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Inhibition of enzymatic synthesis of pantothenate by 2,3-dichloroisobutyrate



Inhibition of enzymatic synthesis of pantothenate by 2,3-dichloroisobutyrate



Science 128(3337): 1509-1510



The investigations reported here have shown that 2,3-dichloroisobuty-rate is uncompetitive with beta-alanine and competitive with pantoate for a site on the enzyme of pantothenate synthesis. The enzyme dissociation constant of the inhibitor was comparable to that of the competitive substrate.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 014082825

Download citation: RISBibTeXText

PMID: 13615304

DOI: 10.1126/science.128.3337.1509


Related references

Chemical and enzymatic synthesis of -pantothenate. Biochimica et Biophysica Acta - General Subjects 86(1): 33-38, 1964

D-Pantothenate synthesis in Corynebacterium glutamicum and use of panBC and genes encoding L-valine synthesis for D-pantothenate overproduction. Applied and Environmental Microbiology 65(5): 1973-1979, 1999

Enzymatic synthesis of beta-[U-14C]alanine and D-[1,2,3-14C]pantothenate of high specific radioactivity. Analytical Biochemistry 103(2): 377-380, 1980

Inhibition of pantothenate synthesis by streptomycin. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine 77(3): 459-461, 1951

Effect of concentration of pantothenate on selection of a mutant for pantothenate synthesis in Saccharomyces cerevisiae. Genetics 35(3): 381-395, 1950

Pantothenate studies. 1. Interferences by D-serine and L-aspartic acid with pantothenate synthesis in Escherichia coli. J. Bacterial, 80: 733-745, 1950

Correlations between pantothenate uptake, phospholipid synthesis and pantothenate-binding protein formation in Pseudomonas fluorescens P-2. Acta Chemica Scandinavica. Series B: Organic Chemistry and Biochemistry 28(1): 78-84, 1974

Correlations between pantothenate uptake phospho lipid synthesis and pantothenate binding protein formation in pseudomonas fluorescens strain p 2. Acta Chemica Scandinavica Series B Organic Chemistry & Biochemistry 28(1): 78-84, 1974

Inhibition Of D-Pantothenate By L-Pantothenate In The Rat. American Journal of Clinical Nutrition 13: 378-384, 1963

Chemical And Enzymatic Syntheses Of Gamma-Pantothenate. Biochimica et Biophysica Acta 86: 33-38, 1964

Synthesis, enzymatic inhibition, and cancer cell growth inhibition of novel delta-lactam-based histone deacetylase (HDAC) inhibitors. Bioorganic & Medicinal Chemistry Letters 16(15): 4068-4070, 2006

Stepwise oligo nucleotide synthesis part 26 preliminary enzymatic synthesis of di nucleoside mono phosphates and the approaches to enzyme inhibition. Bioorganicheskaya Khimiya 4(6): 740-744, 1978

Stepwise synthesis of oligo nucleotides 26. enzymatic synthesis of di nucleoside mono phosphates on the preparative scale and approaches to the inhibition of the enzyme. Soviet Journal of Bioorganic Chemistry 4(6): 533-536, 1978

Studies on enzymatic synthesis of acid amide and peptide binding. II. The mechanism of fluoride inhibition of glutamine synthesis and prosthetic group of enzyme. Acta Physiologica Academiae Scientiarum Hungaricae 6(2-3): 201-208, 1954

Investigations on pantothenic acid and its related compounds. XX. Biochemical studies. 11. Enzymatic conversion of 2'-ketopantothenate to D-pantothenate in rat. Journal of Biochemistry 65(2): 209-214, 1969