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Inhibition of enzymatic synthesis of pantothenate by 2,3-dichloroisobutyrate

Inhibition of enzymatic synthesis of pantothenate by 2,3-dichloroisobutyrate

Science 128(3337): 1509-1510

The investigations reported here have shown that 2,3-dichloroisobuty-rate is uncompetitive with beta-alanine and competitive with pantoate for a site on the enzyme of pantothenate synthesis. The enzyme dissociation constant of the inhibitor was comparable to that of the competitive substrate.

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Accession: 014082825

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PMID: 13615304

DOI: 10.1126/science.128.3337.1509

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