Inhibition of enzymatic synthesis of pantothenate by 2,3-dichloroisobutyrate
Inhibition of enzymatic synthesis of pantothenate by 2,3-dichloroisobutyrate
Hilton, J.L.
Science 128(3337): 1509-1510
1958
The investigations reported here have shown that 2,3-dichloroisobuty-rate is uncompetitive with beta-alanine and competitive with pantoate for a site on the enzyme of pantothenate synthesis. The enzyme dissociation constant of the inhibitor was comparable to that of the competitive substrate.