Inhibition of intrinsic factor by pernicious anaemia sera

Taylor, K. B.

The absorption of vitamin B12 after an oral dose of 60Co-vitamin B12 with intrinsic factor was estimated by the faecal excretion method. In patients with pernicious anaemia absorption was less when serum from other patients who had been treated by the oral route was added to the intrinsic factor of the test dose than when serum from normal subjects was added; absorption from the test dose without serum did not differ significantly from that with normal serum.