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Inhibition Of Lactogenesis By Combined Oral Progestogens And Oestrogens



Inhibition Of Lactogenesis By Combined Oral Progestogens And Oestrogens



Lancet 2(7303): 322-324



2 oral progestogens[long dash]6-alpha-methyl-17-hydroxyprogesterone acetate, alone and with added ethinyl-estradlol, and 17-alpha-ethinyl-17-hydroxy-5(10)-estren-3-one, with added ethinyl-estradiol-3-methyl-ether[long dash]were used in 86 women for inhibition of lactogenesis. The progestogen-estrogen combinations proved to be most effective. The positive results are consistent with the present views on the mechanism of lactogenesis in animals, which emphasise the role of progesterone-estrogen in synerglstlc doses in stimulation of mammary growth, prevention of lactation during pregnancy, and inhibition of lactogenesis.

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Accession: 014082878

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PMID: 14044268


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